5I49
RNA Editing TUTase 1 from Trypanosoma brucei in complex with UTP analog UMPNPP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS195 |
| A | CYS198 |
| A | HIS212 |
| A | HIS217 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue 2KH A 702 |
| Chain | Residue |
| A | LYS505 |
| A | LYS509 |
| A | SER523 |
| A | TYR524 |
| A | MG703 |
| A | HOH820 |
| A | HOH848 |
| A | HOH850 |
| A | HOH858 |
| A | HOH882 |
| A | HOH932 |
| A | HOH935 |
| A | HOH963 |
| A | HOH998 |
| A | HOH1141 |
| A | SER298 |
| A | PHE479 |
| A | GLY480 |
| A | ASN483 |
| A | SER484 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | 2KH702 |
| A | HOH848 |
| A | HOH858 |
| A | HOH998 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 31 |
| Details | ZN_FING: C2H2-type; atypical => ECO:0000269|PubMed:27744351 |
| Chain | Residue | Details |
| A | VAL190-LEU221 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27744351, ECO:0007744|PDB:5HZD, ECO:0007744|PDB:5I49 |
| Chain | Residue | Details |
| A | CYS195 | |
| A | CYS198 | |
| A | HIS212 | |
| A | HIS217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q381M1 |
| Chain | Residue | Details |
| A | SER298 | |
| A | ALA309 | |
| A | ARG358 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q86MV5 |
| Chain | Residue | Details |
| A | ASP310 | |
| A | ASP312 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27744351, ECO:0007744|PDB:5I49, ECO:0007744|PDB:5IDO |
| Chain | Residue | Details |
| A | GLY480 | |
| A | LYS505 | |
| A | LYS509 | |
| A | SER523 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for catalytic activity => ECO:0000250|UniProtKB:Q86MV5 |
| Chain | Residue | Details |
| A | ASP473 |
