5I3K
Structure-Function Studies on Role of Hydrophobic Clamping of a Basic Glutamate in Catalysis by Triosephosphate Isomerase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004807 | molecular_function | triose-phosphate isomerase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005777 | cellular_component | peroxisome |
A | 0005829 | cellular_component | cytosol |
A | 0006094 | biological_process | gluconeogenesis |
A | 0006096 | biological_process | glycolytic process |
A | 0016853 | molecular_function | isomerase activity |
A | 0019563 | biological_process | glycerol catabolic process |
A | 0020015 | cellular_component | glycosome |
A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
B | 0004807 | molecular_function | triose-phosphate isomerase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005777 | cellular_component | peroxisome |
B | 0005829 | cellular_component | cytosol |
B | 0006094 | biological_process | gluconeogenesis |
B | 0006096 | biological_process | glycolytic process |
B | 0016853 | molecular_function | isomerase activity |
B | 0019563 | biological_process | glycerol catabolic process |
B | 0020015 | cellular_component | glycosome |
B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
C | 0004807 | molecular_function | triose-phosphate isomerase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005777 | cellular_component | peroxisome |
C | 0005829 | cellular_component | cytosol |
C | 0006094 | biological_process | gluconeogenesis |
C | 0006096 | biological_process | glycolytic process |
C | 0016853 | molecular_function | isomerase activity |
C | 0019563 | biological_process | glycerol catabolic process |
C | 0020015 | cellular_component | glycosome |
C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
D | 0004807 | molecular_function | triose-phosphate isomerase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005777 | cellular_component | peroxisome |
D | 0005829 | cellular_component | cytosol |
D | 0006094 | biological_process | gluconeogenesis |
D | 0006096 | biological_process | glycolytic process |
D | 0016853 | molecular_function | isomerase activity |
D | 0019563 | biological_process | glycerol catabolic process |
D | 0020015 | cellular_component | glycosome |
D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue NA A 301 |
Chain | Residue |
A | ALA160 |
A | HOH429 |
A | HOH469 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue NA A 302 |
Chain | Residue |
A | HOH473 |
A | HOH497 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue PGA B 301 |
Chain | Residue |
B | GLY173 |
B | GLY234 |
B | GLY235 |
B | HOH405 |
B | HOH421 |
B | HOH445 |
B | HOH447 |
B | LYS13 |
B | GLU167 |
B | ALA171 |
B | ILE172 |
site_id | AC4 |
Number of Residues | 13 |
Details | binding site for residue PGA C 301 |
Chain | Residue |
C | LYS13 |
C | GLU167 |
C | ALA171 |
C | ILE172 |
C | GLY173 |
C | GLY212 |
C | VAL214 |
C | ALA232 |
C | GLY234 |
C | GLY235 |
C | HOH421 |
C | HOH426 |
C | HOH448 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue NA C 302 |
Chain | Residue |
C | PHE74 |
C | HOH479 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue PGA D 301 |
Chain | Residue |
D | LYS13 |
D | GLU167 |
D | ILE172 |
D | GLY173 |
D | GLY212 |
D | ALA232 |
D | GLY234 |
D | GLY235 |
D | HOH426 |
D | HOH433 |
Functional Information from PROSITE/UniProt
site_id | PS00171 |
Number of Residues | 11 |
Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
Chain | Residue | Details |
A | ALA165-GLY175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Electrophile |
Chain | Residue | Details |
A | HIS95 | |
B | HIS95 | |
C | HIS95 | |
D | HIS95 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | GLU167 | |
B | GLU167 | |
C | GLU167 | |
D | GLU167 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN11 | |
A | LYS13 | |
B | ASN11 | |
B | LYS13 | |
C | ASN11 | |
C | LYS13 | |
D | ASN11 | |
D | LYS13 |