5I3K
Structure-Function Studies on Role of Hydrophobic Clamping of a Basic Glutamate in Catalysis by Triosephosphate Isomerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0020015 | cellular_component | glycosome |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0020015 | cellular_component | glycosome |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| C | 0004807 | molecular_function | triose-phosphate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019563 | biological_process | glycerol catabolic process |
| C | 0020015 | cellular_component | glycosome |
| C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| D | 0004807 | molecular_function | triose-phosphate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019563 | biological_process | glycerol catabolic process |
| D | 0020015 | cellular_component | glycosome |
| D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | ALA160 |
| A | HOH429 |
| A | HOH469 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | HOH473 |
| A | HOH497 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue PGA B 301 |
| Chain | Residue |
| B | GLY173 |
| B | GLY234 |
| B | GLY235 |
| B | HOH405 |
| B | HOH421 |
| B | HOH445 |
| B | HOH447 |
| B | LYS13 |
| B | GLU167 |
| B | ALA171 |
| B | ILE172 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue PGA C 301 |
| Chain | Residue |
| C | LYS13 |
| C | GLU167 |
| C | ALA171 |
| C | ILE172 |
| C | GLY173 |
| C | GLY212 |
| C | VAL214 |
| C | ALA232 |
| C | GLY234 |
| C | GLY235 |
| C | HOH421 |
| C | HOH426 |
| C | HOH448 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue NA C 302 |
| Chain | Residue |
| C | PHE74 |
| C | HOH479 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue PGA D 301 |
| Chain | Residue |
| D | LYS13 |
| D | GLU167 |
| D | ILE172 |
| D | GLY173 |
| D | GLY212 |
| D | ALA232 |
| D | GLY234 |
| D | GLY235 |
| D | HOH426 |
| D | HOH433 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
| Chain | Residue | Details |
| A | ALA165-GLY175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Electrophile"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
