5I3I

Structure-Function Studies on Role of Hydrophobic Clamping of a Basic Glutamate in Catalysis by Triosephosphate Isomerase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0020015	cellular_component	glycosome
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0020015	cellular_component	glycosome
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0020015	cellular_component	glycosome
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0020015	cellular_component	glycosome
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue PGA A 301

Chain	Residue
A	ASN11
A	GLY235
A	HOH406
A	HOH418
A	HOH438
A	HOH459
A	LYS13
A	HIS95
A	GLU167
A	ALA171
A	GLY173
A	GLY212
A	SER213
A	GLY234

---

site_id	AC2
Number of Residues	14
Details	binding site for residue PGA B 301

Chain	Residue
B	ASN11
B	LYS13
B	HIS95
B	GLU167
B	ALA171
B	ALA172
B	GLY173
B	GLY212
B	SER213
B	GLY234
B	GLY235
B	HOH406
B	HOH440
B	HOH450

---

site_id	AC3
Number of Residues	13
Details	binding site for residue PGA C 301

Chain	Residue
C	ASN11
C	LYS13
C	HIS95
C	GLU167
C	ALA171
C	GLY173
C	GLY212
C	SER213
C	GLY234
C	GLY235
C	HOH410
C	HOH417
C	HOH438

---

site_id	AC4
Number of Residues	15
Details	binding site for residue PGA D 301

Chain	Residue
D	ASN11
D	LYS13
D	HIS95
D	GLU167
D	ALA171
D	ALA172
D	GLY173
D	GLY212
D	SER213
D	GLY234
D	GLY235
D	HOH401
D	HOH419
D	HOH433
D	HOH447

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Electrophile

Chain	Residue	Details
A	HIS95
B	HIS95
C	HIS95
D	HIS95

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	GLU167
B	GLU167
C	GLU167
D	GLU167

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	ASN11
A	LYS13
B	ASN11
B	LYS13
C	ASN11
C	LYS13
D	ASN11
D	LYS13

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