Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HZ9

human FABP3 in complex with 6-Chloro-2-methyl-4-phenyl-quinoline-3-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008092	molecular_function	cytoskeletal protein binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008289	molecular_function	lipid binding
A	0015909	biological_process	long-chain fatty acid transport
A	0032365	biological_process	intracellular lipid transport
A	0036041	molecular_function	long-chain fatty acid binding
A	0042632	biological_process	cholesterol homeostasis
A	0046320	biological_process	regulation of fatty acid oxidation
A	0050873	biological_process	brown fat cell differentiation
A	0055091	biological_process	phospholipid homeostasis
A	0070062	cellular_component	extracellular exosome
A	0070538	molecular_function	oleic acid binding
A	0071073	biological_process	positive regulation of phospholipid biosynthetic process
A	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
A	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008092	molecular_function	cytoskeletal protein binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0008289	molecular_function	lipid binding
B	0015909	biological_process	long-chain fatty acid transport
B	0032365	biological_process	intracellular lipid transport
B	0036041	molecular_function	long-chain fatty acid binding
B	0042632	biological_process	cholesterol homeostasis
B	0046320	biological_process	regulation of fatty acid oxidation
B	0050873	biological_process	brown fat cell differentiation
B	0055091	biological_process	phospholipid homeostasis
B	0070062	cellular_component	extracellular exosome
B	0070538	molecular_function	oleic acid binding
B	0071073	biological_process	positive regulation of phospholipid biosynthetic process
B	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
B	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008092	molecular_function	cytoskeletal protein binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008289	molecular_function	lipid binding
C	0015909	biological_process	long-chain fatty acid transport
C	0032365	biological_process	intracellular lipid transport
C	0036041	molecular_function	long-chain fatty acid binding
C	0042632	biological_process	cholesterol homeostasis
C	0046320	biological_process	regulation of fatty acid oxidation
C	0050873	biological_process	brown fat cell differentiation
C	0055091	biological_process	phospholipid homeostasis
C	0070062	cellular_component	extracellular exosome
C	0070538	molecular_function	oleic acid binding
C	0071073	biological_process	positive regulation of phospholipid biosynthetic process
C	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
C	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008092	molecular_function	cytoskeletal protein binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0008289	molecular_function	lipid binding
D	0015909	biological_process	long-chain fatty acid transport
D	0032365	biological_process	intracellular lipid transport
D	0036041	molecular_function	long-chain fatty acid binding
D	0042632	biological_process	cholesterol homeostasis
D	0046320	biological_process	regulation of fatty acid oxidation
D	0050873	biological_process	brown fat cell differentiation
D	0055091	biological_process	phospholipid homeostasis
D	0070062	cellular_component	extracellular exosome
D	0070538	molecular_function	oleic acid binding
D	0071073	biological_process	positive regulation of phospholipid biosynthetic process
D	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
D	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008092	molecular_function	cytoskeletal protein binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0008289	molecular_function	lipid binding
E	0015909	biological_process	long-chain fatty acid transport
E	0032365	biological_process	intracellular lipid transport
E	0036041	molecular_function	long-chain fatty acid binding
E	0042632	biological_process	cholesterol homeostasis
E	0046320	biological_process	regulation of fatty acid oxidation
E	0050873	biological_process	brown fat cell differentiation
E	0055091	biological_process	phospholipid homeostasis
E	0070062	cellular_component	extracellular exosome
E	0070538	molecular_function	oleic acid binding
E	0071073	biological_process	positive regulation of phospholipid biosynthetic process
E	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
E	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008092	molecular_function	cytoskeletal protein binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0008289	molecular_function	lipid binding
F	0015909	biological_process	long-chain fatty acid transport
F	0032365	biological_process	intracellular lipid transport
F	0036041	molecular_function	long-chain fatty acid binding
F	0042632	biological_process	cholesterol homeostasis
F	0046320	biological_process	regulation of fatty acid oxidation
F	0050873	biological_process	brown fat cell differentiation
F	0055091	biological_process	phospholipid homeostasis
F	0070062	cellular_component	extracellular exosome
F	0070538	molecular_function	oleic acid binding
F	0071073	biological_process	positive regulation of phospholipid biosynthetic process
F	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
F	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0008092	molecular_function	cytoskeletal protein binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0008289	molecular_function	lipid binding
G	0015909	biological_process	long-chain fatty acid transport
G	0032365	biological_process	intracellular lipid transport
G	0036041	molecular_function	long-chain fatty acid binding
G	0042632	biological_process	cholesterol homeostasis
G	0046320	biological_process	regulation of fatty acid oxidation
G	0050873	biological_process	brown fat cell differentiation
G	0055091	biological_process	phospholipid homeostasis
G	0070062	cellular_component	extracellular exosome
G	0070538	molecular_function	oleic acid binding
G	0071073	biological_process	positive regulation of phospholipid biosynthetic process
G	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
G	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008092	molecular_function	cytoskeletal protein binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0008289	molecular_function	lipid binding
H	0015909	biological_process	long-chain fatty acid transport
H	0032365	biological_process	intracellular lipid transport
H	0036041	molecular_function	long-chain fatty acid binding
H	0042632	biological_process	cholesterol homeostasis
H	0046320	biological_process	regulation of fatty acid oxidation
H	0050873	biological_process	brown fat cell differentiation
H	0055091	biological_process	phospholipid homeostasis
H	0070062	cellular_component	extracellular exosome
H	0070538	molecular_function	oleic acid binding
H	0071073	biological_process	positive regulation of phospholipid biosynthetic process
H	0140214	biological_process	positive regulation of long-chain fatty acid import into cell
H	2001245	biological_process	regulation of phosphatidylcholine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 201

Chain	Residue
A	SER14
A	LYS15
A	ASN16
A	PHE17
A	ASP18
H	LYS53
H	HIS55

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	PRO39
A	SER56
A	THR57
A	THR37
A	LYS38

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 203

Chain	Residue
A	LYS59
A	ASN60
B	LYS80

site_id	AC4
Number of Residues	9
Details	binding site for residue 5M8 A 204

Chain	Residue
A	MET21
A	THR54
A	SER56
A	PHE58
A	ASP77
A	LEU105
A	TYR129
A	HOH301
A	HOH307

site_id	AC5
Number of Residues	11
Details	binding site for residue 5M8 A 205

Chain	Residue
A	LYS22
A	5M8206
E	MET36
G	THR30
G	VAL33
G	PHE58
G	5M8206
G	5M8207
H	THR57
H	PHE58
H	5M8204

site_id	AC6
Number of Residues	11
Details	binding site for residue 5M8 A 206

Chain	Residue
A	LYS22
A	GLY27
A	PHE28
A	ARG31
A	5M8205
A	HOH334
B	5M8205
E	GLN32
G	ALA29
G	5M8207
H	THR57

site_id	AC7
Number of Residues	10
Details	binding site for residue SO4 B 201

Chain	Residue
B	SER14
B	LYS15
B	ASN16
B	PHE17
B	ASP18
B	SER35
B	HOH328
B	HOH334
F	LYS53
F	HIS55

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 202

Chain	Residue
B	THR37
B	LYS38
B	PRO39
B	SER56
B	THR57

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 B 203

Chain	Residue
B	LYS59
B	ASN60

site_id	AD1
Number of Residues	13
Details	binding site for residue 5M8 B 204

Chain	Residue
B	PHE17
B	MET21
B	THR37
B	PRO39
B	THR54
B	SER56
B	ASP77
B	LEU105
B	TYR129
B	HOH301
B	HOH305
B	HOH313
B	HOH335

site_id	AD2
Number of Residues	9
Details	binding site for residue 5M8 B 205

Chain	Residue
A	5M8206
B	GLY25
B	GLY27
B	PHE28
B	ARG31
B	HOH332
F	THR57
G	PHE28
G	GLN32

site_id	AD3
Number of Residues	11
Details	binding site for residue SO4 C 201

Chain	Residue
C	SER14
C	LYS15
C	ASN16
C	PHE17
C	ASP18
C	SER35
C	HOH317
C	HOH334
E	LYS53
E	HIS55
E	HOH308

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 C 202

Chain	Residue
C	THR57
C	THR37
C	LYS38
C	SER56

site_id	AD5
Number of Residues	9
Details	binding site for residue 5M8 C 203

Chain	Residue
C	MET21
C	THR37
C	THR54
C	SER56
C	LYS59
C	ALA76
C	ASP77
C	TYR129
C	HOH303

site_id	AD6
Number of Residues	11
Details	binding site for residue 5M8 C 204

Chain	Residue
C	VAL26
C	GLY27
C	PHE28
C	ARG31
C	HOH301
C	HOH311
E	THR57
E	5M8205
F	ALA29
G	5M8205
G	HOH302

site_id	AD7
Number of Residues	10
Details	binding site for residue SO4 D 201

Chain	Residue
D	SER14
D	LYS15
D	ASN16
D	PHE17
D	ASP18
D	HOH318
D	HOH336
G	LYS53
G	HIS55
G	HOH305

site_id	AD8
Number of Residues	4
Details	binding site for residue SO4 D 202

Chain	Residue
D	THR37
D	LYS38
D	SER56
D	THR57

site_id	AD9
Number of Residues	12
Details	binding site for residue 5M8 D 203

Chain	Residue
D	PHE17
D	MET21
D	THR37
D	THR54
D	SER56
D	PHE58
D	ALA76
D	ASP77
D	TYR129
D	HOH301
D	HOH312
D	HOH323

site_id	AE1
Number of Residues	7
Details	binding site for residue SO4 E 201

Chain	Residue
E	SER14
E	LYS15
E	ASN16
E	PHE17
E	ASP18
E	HOH335
H	LYS38

site_id	AE2
Number of Residues	6
Details	binding site for residue SO4 E 202

Chain	Residue
A	ALA29
B	ASP99
E	ASP18
E	LYS22
E	ARG31
E	GLN32

site_id	AE3
Number of Residues	7
Details	binding site for residue SO4 E 203

Chain	Residue
B	SER23
B	HOH314
E	GLY27
E	ALA29
E	THR30
E	HOH314
E	HOH326

site_id	AE4
Number of Residues	7
Details	binding site for residue 5M8 E 204

Chain	Residue
E	THR54
E	SER56
E	LYS59
E	ALA76
E	HOH302
E	HOH310
E	HOH311

site_id	AE5
Number of Residues	8
Details	binding site for residue 5M8 E 205

Chain	Residue
C	LYS22
C	5M8204
E	VAL33
E	MET36
E	THR57
E	HOH324
G	5M8205
G	5M8207

site_id	AE6
Number of Residues	9
Details	binding site for residue SO4 F 201

Chain	Residue
F	SER14
F	LYS15
F	ASN16
F	PHE17
F	ASP18
F	HOH308
F	HOH311
F	HOH332
G	VAL12

site_id	AE7
Number of Residues	2
Details	binding site for residue SO4 F 202

Chain	Residue
B	GLN32
F	LYS10

site_id	AE8
Number of Residues	5
Details	binding site for residue SO4 F 203

Chain	Residue
F	ASP18
F	LYS22
F	PHE28
F	ARG31
G	LYS38

site_id	AE9
Number of Residues	11
Details	binding site for residue 5M8 F 204

Chain	Residue
F	PHE17
F	MET21
F	THR54
F	SER56
F	ALA76
F	ASP77
F	LEU105
F	TYR129
F	HOH301
F	HOH316
F	HOH317

site_id	AF1
Number of Residues	7
Details	binding site for residue SO4 G 201

Chain	Residue
F	LYS38
G	SER14
G	LYS15
G	ASN16
G	PHE17
G	ASP18
G	HOH341

site_id	AF2
Number of Residues	6
Details	binding site for residue SO4 G 202

Chain	Residue
A	ASP99
B	ALA29
G	ASP18
G	LYS22
G	ARG31
G	GLN32

site_id	AF3
Number of Residues	4
Details	binding site for residue CL G 203

Chain	Residue
G	ALA34
G	THR37
G	ARG127
G	5M8204

site_id	AF4
Number of Residues	8
Details	binding site for residue 5M8 G 204

Chain	Residue
G	THR30
G	THR54
G	SER56
G	ALA76
G	CL203
G	HOH308
G	HOH316
G	HOH317

site_id	AF5
Number of Residues	9
Details	binding site for residue 5M8 G 205

Chain	Residue
C	5M8204
D	LYS22
D	PHE28
D	ARG31
E	5M8205
G	THR57
G	5M8207
G	HOH302
H	5M8204

site_id	AF6
Number of Residues	6
Details	binding site for residue 5M8 G 206

Chain	Residue
A	5M8205
G	PHE58
G	LYS59
G	ASP78
H	PHE58
H	5M8204

site_id	AF7
Number of Residues	10
Details	binding site for residue 5M8 G 207

Chain	Residue
A	5M8205
A	5M8206
E	5M8205
F	VAL33
G	VAL33
G	MET36
G	THR57
G	5M8205
G	HOH301
H	5M8204

site_id	AF8
Number of Residues	9
Details	binding site for residue SO4 H 201

Chain	Residue
E	VAL12
H	SER14
H	LYS15
H	ASN16
H	PHE17
H	ASP18
H	HOH323
H	HOH325
H	HOH337

site_id	AF9
Number of Residues	2
Details	binding site for residue CL H 202

Chain	Residue
H	ASP18
H	ARG31

site_id	AG1
Number of Residues	10
Details	binding site for residue 5M8 H 203

Chain	Residue
H	MET21
H	THR54
H	SER56
H	PHE58
H	ASP77
H	LEU105
H	TYR129
H	HOH301
H	HOH304
H	HOH317

site_id	AG2
Number of Residues	10
Details	binding site for residue 5M8 H 204

Chain	Residue
A	5M8205
G	5M8205
G	5M8206
G	5M8207
G	HOH322
H	ALA29
H	THR30
H	LYS59
H	ALA76
H	ASP78

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWkLvdSkNFDdYMKSL

Chain	Residue	Details
A	GLY7-LEU24

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:7922029, ECO:0007744\|PDB:1HMT

Chain	Residue	Details
A	ARG127
B	ARG127
C	ARG127
D	ARG127
E	ARG127
F	ARG127
G	ARG127
H	ARG127

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylvaline => ECO:0007744\|PubMed:22223895

Chain	Residue	Details
A	VAL2
B	VAL2
C	VAL2
D	VAL2
E	VAL2
F	VAL2
G	VAL2
H	VAL2

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07483

Chain	Residue	Details
A	THR8
E	THR30
F	THR8
F	THR30
G	THR8
G	THR30
H	THR8
H	THR30
A	THR30
B	THR8
B	THR30
C	THR8
C	THR30
D	THR8
D	THR30
E	THR8

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000250\|UniProtKB:P07483

Chain	Residue	Details
A	TYR20
B	TYR20
C	TYR20
D	TYR20
E	TYR20
F	TYR20
G	TYR20
H	TYR20

site_id	SWS_FT_FI5
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P07483

Chain	Residue	Details
A	SER23
E	SER83
F	SER23
F	SER83
G	SER23
G	SER83
H	SER23
H	SER83
A	SER83
B	SER23
B	SER83
C	SER23
C	SER83
D	SER23
D	SER83
E	SER23

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)