5HYA

Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchangerNCX_Mj soaked with 150 mM Na+ and nominal Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0008273	molecular_function	calcium, potassium:sodium antiporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 401

Chain	Residue
A	ALA47
A	THR50
A	SER51
A	GLU213
A	SER236

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 402

Chain	Residue
A	THR50
A	GLU54
A	THR209
A	GLU213

---

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 403

Chain	Residue
A	GLU54
A	SER77
A	ALA206
A	THR209
A	SER210

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 404

Chain	Residue
A	ILE118
A	ASP121
A	GLY122
A	ASP127
A	OLC409
A	HOH573

---

site_id	AC5
Number of Residues	2
Details	binding site for residue ACT A 405

Chain	Residue
A	ILE14
A	HOH503

---

site_id	AC6
Number of Residues	1
Details	binding site for residue ACT A 406

Chain	Residue
A	TYR60

---

site_id	AC7
Number of Residues	2
Details	binding site for residue ACT A 407

Chain	Residue
A	LEU193
A	HOH501

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT A 408

Chain	Residue
A	ASN35
A	LYS279
A	HOH530
A	HOH535

---

site_id	AC9
Number of Residues	9
Details	binding site for residue OLC A 409

Chain	Residue
A	ILE113
A	VAL117
A	ILE118
A	ASP121
A	ASP127
A	ALA186
A	CA404
A	OLC410
A	OLC411

---

site_id	AD1
Number of Residues	12
Details	binding site for residue OLC A 410

Chain	Residue
A	PHE9
A	PHE111
A	PHE114
A	ILE118
A	ILE126
A	ASP127
A	LEU134
A	TYR138
A	OLC409
A	OLC411
A	OLC423
A	HOH505

---

site_id	AD2
Number of Residues	7
Details	binding site for residue OLC A 411

Chain	Residue
A	PHE182
A	ALA190
A	ASP197
A	LYS198
A	GLY201
A	OLC409
A	OLC410

---

site_id	AD3
Number of Residues	1
Details	binding site for residue MYS A 412

Chain	Residue
A	ASN258

---

site_id	AD4
Number of Residues	2
Details	binding site for residue MYS A 414

Chain	Residue
A	TRP283
A	ILE286

---

site_id	AD5
Number of Residues	5
Details	binding site for residue 1PE A 415

Chain	Residue
A	TYR17
A	SER20
A	MET215
A	LYS222
A	OLC423

---

site_id	AD6
Number of Residues	4
Details	binding site for residue MYS A 417

Chain	Residue
A	ILE136
A	ARG140
A	ALA297
A	MYS421

---

site_id	AD7
Number of Residues	5
Details	binding site for residue MYS A 418

Chain	Residue
A	ILE91
A	TRP125
A	LEU250
A	ARG282
A	ILE293

---

site_id	AD8
Number of Residues	5
Details	binding site for residue MYS A 419

Chain	Residue
A	VAL259
A	LEU291
A	SER298
A	LEU299
A	ARG300

---

site_id	AD9
Number of Residues	3
Details	binding site for residue MYS A 421

Chain	Residue
A	ILE293
A	SER298
A	MYS417

---

site_id	AE1
Number of Residues	6
Details	binding site for residue OLC A 422

Chain	Residue
A	PRO53
A	LEU172
A	LEU176
A	ALA179
A	GLU180
A	GLY208

---

site_id	AE2
Number of Residues	13
Details	binding site for residue OLC A 423

Chain	Residue
A	HOH504
A	HOH506
A	CYS80
A	LEU84
A	LEU88
A	ILE137
A	THR203
A	LEU204
A	ALA206
A	PHE207
A	TYR292
A	OLC410
A	1PE415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE3-PHE23
A	PHE39-ALA59
A	SER77-VAL97
A	LEU106-ILE126
A	GLY128-ALA148
A	PHE163-VAL183
A	VAL199-ALA219
A	GLY227-VAL247
A	LEU254-PHE274

---