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5HY5

Crystal Structure of a Tryptophan 6-halogenase (SttH) from Streptomyces toxytricini

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0004497molecular_functionmonooxygenase activity
A0016491molecular_functionoxidoreductase activity
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004497molecular_functionmonooxygenase activity
B0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues34
Detailsbinding site for residue FAD A 601
ChainResidue
AGLY13
AVAL48
AGLY49
AALA51
AASP201
AVAL203
ACYS233
ATHR234
AGLY235
AARG237
ALEU354
AGLY14
APHE358
APRO361
ASER364
AGLY366
AILE367
AILE370
ACL602
AHOH701
AHOH710
AHOH715
AGLY15
AHOH722
AHOH725
AHOH733
AHOH734
AHOH768
ATHR16
AALA17
ASER40
AILE43
ATHR45
AVAL46

site_idAC2
Number of Residues6
Detailsbinding site for residue CL A 602
ChainResidue
APRO361
ASER364
ATHR365
AGLY366
AFAD601
AHOH735

site_idAC3
Number of Residues30
Detailsbinding site for residue FAD B 601
ChainResidue
BGLY13
BGLY14
BGLY15
BALA17
BSER40
BILE43
BTHR45
BVAL46
BVAL48
BGLY49
BALA51
BVAL203
BCYS233
BTHR234
BGLY235
BTRP290
BGLY353
BLEU354
BPHE358
BPRO361
BSER364
BGLY366
BILE367
BILE370
BCL602
BHOH708
BHOH710
BHOH730
BHOH735
BHOH767

site_idAC4
Number of Residues5
Detailsbinding site for residue CL B 602
ChainResidue
BPRO361
BSER364
BTHR365
BGLY366
BFAD601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P95480
ChainResidueDetails
ALYS79
BLYS79

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING: BINDING => ECO:0007744|PDB:5HY5
ChainResidueDetails
AGLY14
BGLY14
BSER40
BILE43
BVAL46
BVAL48
BALA51
BVAL203
BLEU354
BILE367
ASER40
AILE43
AVAL46
AVAL48
AALA51
AVAL203
ALEU354
AILE367

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:A1E280
ChainResidueDetails
APRO97
ATYR456
ATYR457
BPRO97
BTYR456
BTYR457

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26840773, ECO:0007744|PDB:5HY5
ChainResidueDetails
ATHR365
AGLY366
BTHR365
BGLY366

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for activity => ECO:0000250|UniProtKB:P95480
ChainResidueDetails
AGLU363
BGLU363

226707

PDB entries from 2024-10-30

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