5HWS
Crystal structure of ketopantoate reductase from Thermococcus kodakarensis complexed with NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0015940 | biological_process | pantothenate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0015940 | biological_process | pantothenate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0015940 | biological_process | pantothenate biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0015940 | biological_process | pantothenate biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | GLY7 |
| A | LYS74 |
| A | SER77 |
| A | ALA81 |
| A | GLN99 |
| A | ASN100 |
| A | THR120 |
| A | ASN122 |
| A | GLY123 |
| A | ALA124 |
| A | GLU262 |
| A | GLY9 |
| A | HOH508 |
| A | HOH523 |
| A | HOH525 |
| A | HOH535 |
| A | HOH538 |
| A | HOH553 |
| A | HOH558 |
| A | HOH567 |
| A | SER10 |
| A | ILE11 |
| A | ILE29 |
| A | GLY30 |
| A | ARG31 |
| A | ALA72 |
| A | VAL73 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue NAP B 401 |
| Chain | Residue |
| B | GLY7 |
| B | GLY9 |
| B | SER10 |
| B | ILE11 |
| B | GLY30 |
| B | ARG31 |
| B | ALA72 |
| B | VAL73 |
| B | LYS74 |
| B | ALA81 |
| B | ASN100 |
| B | THR120 |
| B | ASN122 |
| B | GLY123 |
| B | ALA124 |
| B | GLU262 |
| B | HOH505 |
| B | HOH549 |
| B | HOH558 |
| B | HOH575 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue NAP C 401 |
| Chain | Residue |
| C | GLY7 |
| C | GLY9 |
| C | SER10 |
| C | ILE11 |
| C | ILE29 |
| C | GLY30 |
| C | ARG31 |
| C | ALA72 |
| C | LYS74 |
| C | ALA81 |
| C | GLN99 |
| C | ASN100 |
| C | THR120 |
| C | ASN122 |
| C | ALA124 |
| C | GLU262 |
| C | HOH515 |
| C | HOH534 |
| C | HOH540 |
| C | HOH542 |
| C | HOH551 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue NAP D 401 |
| Chain | Residue |
| D | GLY7 |
| D | GLY9 |
| D | SER10 |
| D | ILE11 |
| D | ILE29 |
| D | GLY30 |
| D | ARG31 |
| D | ALA72 |
| D | VAL73 |
| D | LYS74 |
| D | ALA81 |
| D | ILE98 |
| D | GLN99 |
| D | ASN100 |
| D | THR120 |
| D | ASN122 |
| D | ALA124 |
| D | GLU262 |
| D | HOH508 |
| D | HOH512 |
| D | HOH539 |
| D | HOH541 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A9J4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26757028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27139828","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26757028","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27139828","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
