5HWO

MvaS in complex with 3-hydroxy-3-methylglutaryl coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
A	0006084	biological_process	acetyl-CoA metabolic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	40
Details	binding site for residue HMG A 501

Chain	Residue
A	ASP31
A	ALA154
A	GLY155
A	THR158
A	PHE192
A	GLY205
A	HIS206
A	SER208
A	TYR212
A	HIS250
A	PRO252
A	ASP31
A	PHE253
A	LYS255
A	LYS259
A	ASN309
A	GLY341
A	SER342
A	HOH606
A	HOH625
A	HOH646
A	HOH649
A	ALA33
A	HOH656
A	HOH690
A	HOH713
A	HOH823
A	HOH841
A	HOH850
A	HOH860
A	HOH865
A	HOH898
A	HOH916
A	LYS34
A	HOH934
A	GLY38
A	GLU83
A	ALA114
A	CYS115
A	TYR149

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 502

Chain	Residue
A	GLY40
A	CYS254
A	LEU301
A	SER305
A	HOH620
A	HOH624
A	HOH650

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 503

Chain	Residue
A	THR84
A	GLY85
A	HIS88
A	ARG194
A	HOH618
A	HOH697
A	HOH852

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site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 504

Chain	Residue
A	LYS101
A	LYS101
A	LEU102
A	LEU102
A	HOH683
A	HOH683
A	HOH856
A	HOH876
A	HOH951

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 505

Chain	Residue
A	ILE65
A	ARG66
A	ASP69
A	HIS206
A	TYR207
A	HOH658
A	HOH863

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site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 506

Chain	Residue
A	ARG246
A	GLN333
A	HOH655
A	HOH828

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site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 A 507

Chain	Residue
A	GLN324
A	LEU366
A	GLU367
A	HOH602
A	HOH616
A	HOH696
A	HOH854

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