Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HW8

Candida albicans FKBP12 P104G protein bound with FK506 in C2 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005527	molecular_function	macrolide binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006366	biological_process	transcription by RNA polymerase II
A	0006457	biological_process	protein folding
A	0016853	molecular_function	isomerase activity
A	0044183	molecular_function	protein folding chaperone
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0062040	cellular_component	fungal biofilm matrix
A	0070651	biological_process	nonfunctional rRNA decay
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1901710	biological_process	regulation of homoserine biosynthetic process
A	1901711	biological_process	negative regulation of homoserine biosynthetic process
A	1903332	biological_process	regulation of protein folding
B	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005527	molecular_function	macrolide binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006366	biological_process	transcription by RNA polymerase II
B	0006457	biological_process	protein folding
B	0016853	molecular_function	isomerase activity
B	0044183	molecular_function	protein folding chaperone
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0062040	cellular_component	fungal biofilm matrix
B	0070651	biological_process	nonfunctional rRNA decay
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1901710	biological_process	regulation of homoserine biosynthetic process
B	1901711	biological_process	negative regulation of homoserine biosynthetic process
B	1903332	biological_process	regulation of protein folding
C	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005527	molecular_function	macrolide binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0006325	biological_process	chromatin organization
C	0006366	biological_process	transcription by RNA polymerase II
C	0006457	biological_process	protein folding
C	0016853	molecular_function	isomerase activity
C	0044183	molecular_function	protein folding chaperone
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0062040	cellular_component	fungal biofilm matrix
C	0070651	biological_process	nonfunctional rRNA decay
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	1901710	biological_process	regulation of homoserine biosynthetic process
C	1901711	biological_process	negative regulation of homoserine biosynthetic process
C	1903332	biological_process	regulation of protein folding
D	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005527	molecular_function	macrolide binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0006325	biological_process	chromatin organization
D	0006366	biological_process	transcription by RNA polymerase II
D	0006457	biological_process	protein folding
D	0016853	molecular_function	isomerase activity
D	0044183	molecular_function	protein folding chaperone
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0062040	cellular_component	fungal biofilm matrix
D	0070651	biological_process	nonfunctional rRNA decay
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	1901710	biological_process	regulation of homoserine biosynthetic process
D	1901711	biological_process	negative regulation of homoserine biosynthetic process
D	1903332	biological_process	regulation of protein folding
E	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005527	molecular_function	macrolide binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0006325	biological_process	chromatin organization
E	0006366	biological_process	transcription by RNA polymerase II
E	0006457	biological_process	protein folding
E	0016853	molecular_function	isomerase activity
E	0044183	molecular_function	protein folding chaperone
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0062040	cellular_component	fungal biofilm matrix
E	0070651	biological_process	nonfunctional rRNA decay
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	1901710	biological_process	regulation of homoserine biosynthetic process
E	1901711	biological_process	negative regulation of homoserine biosynthetic process
E	1903332	biological_process	regulation of protein folding
F	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005527	molecular_function	macrolide binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006366	biological_process	transcription by RNA polymerase II
F	0006457	biological_process	protein folding
F	0016853	molecular_function	isomerase activity
F	0044183	molecular_function	protein folding chaperone
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0062040	cellular_component	fungal biofilm matrix
F	0070651	biological_process	nonfunctional rRNA decay
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	1901710	biological_process	regulation of homoserine biosynthetic process
F	1901711	biological_process	negative regulation of homoserine biosynthetic process
F	1903332	biological_process	regulation of protein folding
G	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0005527	molecular_function	macrolide binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0006325	biological_process	chromatin organization
G	0006366	biological_process	transcription by RNA polymerase II
G	0006457	biological_process	protein folding
G	0016853	molecular_function	isomerase activity
G	0044183	molecular_function	protein folding chaperone
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0062040	cellular_component	fungal biofilm matrix
G	0070651	biological_process	nonfunctional rRNA decay
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	1901710	biological_process	regulation of homoserine biosynthetic process
G	1901711	biological_process	negative regulation of homoserine biosynthetic process
G	1903332	biological_process	regulation of protein folding
H	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005527	molecular_function	macrolide binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0006325	biological_process	chromatin organization
H	0006366	biological_process	transcription by RNA polymerase II
H	0006457	biological_process	protein folding
H	0016853	molecular_function	isomerase activity
H	0044183	molecular_function	protein folding chaperone
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0062040	cellular_component	fungal biofilm matrix
H	0070651	biological_process	nonfunctional rRNA decay
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	1901710	biological_process	regulation of homoserine biosynthetic process
H	1901711	biological_process	negative regulation of homoserine biosynthetic process
H	1903332	biological_process	regulation of protein folding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue FK5 A 201

Chain	Residue
A	TYR30
A	TYR97
A	ILE106
A	HOH306
D	ILE102
D	FK5201
A	ASP41
A	ARG46
A	PHE50
A	GLN58
A	VAL59
A	ILE60
A	TRP63
A	ALA96

site_id	AC2
Number of Residues	12
Details	binding site for residue FK5 B 201

Chain	Residue
B	TYR30
B	PHE40
B	ASP41
B	VAL59
B	ILE60
B	ALA96
B	TYR97
B	PHE114
B	HOH305
E	ILE105
E	FK5201
F	ARG100

site_id	AC3
Number of Residues	11
Details	binding site for residue FK5 C 201

Chain	Residue
C	TYR30
C	PHE40
C	ASP41
C	ARG46
C	GLN58
C	VAL59
C	ILE60
C	TYR97
C	PHE114
C	HOH308
H	FK5201

site_id	AC4
Number of Residues	12
Details	binding site for residue FK5 D 201

Chain	Residue
A	FK5201
D	TYR30
D	PHE40
D	ASP41
D	ARG46
D	PHE50
D	VAL59
D	ILE60
D	ALA96
D	TYR97
D	PHE114
E	ARG100

site_id	AC5
Number of Residues	16
Details	binding site for residue FK5 E 201

Chain	Residue
B	PRO103
B	ILE105
B	FK5201
D	ARG100
E	TYR30
E	PHE40
E	ASP41
E	ARG46
E	PHE50
E	GLN58
E	VAL59
E	ILE60
E	ALA96
E	TYR97
E	ILE102
E	PHE114

site_id	AC6
Number of Residues	14
Details	binding site for residue FK5 F 201

Chain	Residue
B	ARG100
F	TYR30
F	PHE40
F	ASP41
F	PHE50
F	GLN58
F	VAL59
F	ILE60
F	TRP63
F	ALA96
F	TYR97
F	PHE114
G	ILE105
G	FK5201

site_id	AC7
Number of Residues	16
Details	binding site for residue FK5 G 201

Chain	Residue
B	PRO99
F	PRO103
F	ILE105
F	FK5201
G	TYR30
G	PHE40
G	ASP41
G	PHE50
G	GLN58
G	VAL59
G	ILE60
G	TRP63
G	ALA96
G	TYR97
G	ARG100
G	PHE114

site_id	AC8
Number of Residues	12
Details	binding site for residue FK5 H 201

Chain	Residue
H	ASP41
H	PHE50
H	GLN58
H	VAL59
H	ILE60
H	TRP63
H	ILE105
H	PHE114
A	PRO99
C	FK5201
H	TYR30
H	PHE40

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	495
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)