5HW8

Candida albicans FKBP12 P104G protein bound with FK506 in C2 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005527	molecular_function	macrolide binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0006325	biological_process	chromatin organization
A	0006412	biological_process	translation
A	0006457	biological_process	protein folding
A	0045454	biological_process	cell redox homeostasis
A	0062040	cellular_component	fungal biofilm matrix
A	1901710	biological_process	regulation of homoserine biosynthetic process
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005527	molecular_function	macrolide binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006412	biological_process	translation
B	0006457	biological_process	protein folding
B	0045454	biological_process	cell redox homeostasis
B	0062040	cellular_component	fungal biofilm matrix
B	1901710	biological_process	regulation of homoserine biosynthetic process
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005527	molecular_function	macrolide binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0006325	biological_process	chromatin organization
C	0006412	biological_process	translation
C	0006457	biological_process	protein folding
C	0045454	biological_process	cell redox homeostasis
C	0062040	cellular_component	fungal biofilm matrix
C	1901710	biological_process	regulation of homoserine biosynthetic process
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005527	molecular_function	macrolide binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0006325	biological_process	chromatin organization
D	0006412	biological_process	translation
D	0006457	biological_process	protein folding
D	0045454	biological_process	cell redox homeostasis
D	0062040	cellular_component	fungal biofilm matrix
D	1901710	biological_process	regulation of homoserine biosynthetic process
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005527	molecular_function	macrolide binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0006325	biological_process	chromatin organization
E	0006412	biological_process	translation
E	0006457	biological_process	protein folding
E	0045454	biological_process	cell redox homeostasis
E	0062040	cellular_component	fungal biofilm matrix
E	1901710	biological_process	regulation of homoserine biosynthetic process
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005527	molecular_function	macrolide binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006412	biological_process	translation
F	0006457	biological_process	protein folding
F	0045454	biological_process	cell redox homeostasis
F	0062040	cellular_component	fungal biofilm matrix
F	1901710	biological_process	regulation of homoserine biosynthetic process
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0005527	molecular_function	macrolide binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0006325	biological_process	chromatin organization
G	0006412	biological_process	translation
G	0006457	biological_process	protein folding
G	0045454	biological_process	cell redox homeostasis
G	0062040	cellular_component	fungal biofilm matrix
G	1901710	biological_process	regulation of homoserine biosynthetic process
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005527	molecular_function	macrolide binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0006325	biological_process	chromatin organization
H	0006412	biological_process	translation
H	0006457	biological_process	protein folding
H	0045454	biological_process	cell redox homeostasis
H	0062040	cellular_component	fungal biofilm matrix
H	1901710	biological_process	regulation of homoserine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue FK5 A 201

Chain	Residue
A	TYR30
A	TYR97
A	ILE106
A	HOH306
D	ILE102
D	FK5201
A	ASP41
A	ARG46
A	PHE50
A	GLN58
A	VAL59
A	ILE60
A	TRP63
A	ALA96

---

site_id	AC2
Number of Residues	12
Details	binding site for residue FK5 B 201

Chain	Residue
B	TYR30
B	PHE40
B	ASP41
B	VAL59
B	ILE60
B	ALA96
B	TYR97
B	PHE114
B	HOH305
E	ILE105
E	FK5201
F	ARG100

---

site_id	AC3
Number of Residues	11
Details	binding site for residue FK5 C 201

Chain	Residue
C	TYR30
C	PHE40
C	ASP41
C	ARG46
C	GLN58
C	VAL59
C	ILE60
C	TYR97
C	PHE114
C	HOH308
H	FK5201

---

site_id	AC4
Number of Residues	12
Details	binding site for residue FK5 D 201

Chain	Residue
A	FK5201
D	TYR30
D	PHE40
D	ASP41
D	ARG46
D	PHE50
D	VAL59
D	ILE60
D	ALA96
D	TYR97
D	PHE114
E	ARG100

---

site_id	AC5
Number of Residues	16
Details	binding site for residue FK5 E 201

Chain	Residue
B	PRO103
B	ILE105
B	FK5201
D	ARG100
E	TYR30
E	PHE40
E	ASP41
E	ARG46
E	PHE50
E	GLN58
E	VAL59
E	ILE60
E	ALA96
E	TYR97
E	ILE102
E	PHE114

---

site_id	AC6
Number of Residues	14
Details	binding site for residue FK5 F 201

Chain	Residue
B	ARG100
F	TYR30
F	PHE40
F	ASP41
F	PHE50
F	GLN58
F	VAL59
F	ILE60
F	TRP63
F	ALA96
F	TYR97
F	PHE114
G	ILE105
G	FK5201

---

site_id	AC7
Number of Residues	16
Details	binding site for residue FK5 G 201

Chain	Residue
B	PRO99
F	PRO103
F	ILE105
F	FK5201
G	TYR30
G	PHE40
G	ASP41
G	PHE50
G	GLN58
G	VAL59
G	ILE60
G	TRP63
G	ALA96
G	TYR97
G	ARG100
G	PHE114

---

site_id	AC8
Number of Residues	12
Details	binding site for residue FK5 H 201

Chain	Residue
H	ASP41
H	PHE50
H	GLN58
H	VAL59
H	ILE60
H	TRP63
H	ILE105
H	PHE114
A	PRO99
C	FK5201
H	TYR30
H	PHE40

---