5HUV

Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
A	0004805	molecular_function	trehalose-phosphatase activity
A	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
A	0005975	biological_process	carbohydrate metabolic process
A	0005992	biological_process	trehalose biosynthetic process
A	0006623	biological_process	protein targeting to vacuole
A	0016757	molecular_function	glycosyltransferase activity
A	0016758	molecular_function	hexosyltransferase activity
A	0030447	biological_process	filamentous growth
A	0034605	biological_process	cellular response to heat
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0036168	biological_process	filamentous growth of a population of unicellular organisms in response to heat
A	0036180	biological_process	filamentous growth of a population of unicellular organisms in response to biotic stimulus
A	0070413	biological_process	trehalose metabolism in response to stress
A	0071465	biological_process	cellular response to desiccation
B	0003824	molecular_function	catalytic activity
B	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
B	0004805	molecular_function	trehalose-phosphatase activity
B	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
B	0005975	biological_process	carbohydrate metabolic process
B	0005992	biological_process	trehalose biosynthetic process
B	0006623	biological_process	protein targeting to vacuole
B	0016757	molecular_function	glycosyltransferase activity
B	0016758	molecular_function	hexosyltransferase activity
B	0030447	biological_process	filamentous growth
B	0034605	biological_process	cellular response to heat
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0036168	biological_process	filamentous growth of a population of unicellular organisms in response to heat
B	0036180	biological_process	filamentous growth of a population of unicellular organisms in response to biotic stimulus
B	0070413	biological_process	trehalose metabolism in response to stress
B	0071465	biological_process	cellular response to desiccation

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue UPG A 501

Chain	Residue
A	HIS171
A	GLY380
A	MET381
A	ASN382
A	LEU383
A	VAL384
A	GLU387
A	HOH671
A	HOH714
A	HOH739
A	HOH754
A	HIS202
A	HOH796
A	HOH800
A	HOH820
A	VAL278
A	ARG280
A	LYS285
A	SER356
A	ILE357
A	LEU362
A	ASP379

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site_id	AC2
Number of Residues	25
Details	binding site for residue UPG B 501

Chain	Residue
B	TRP98
B	HIS171
B	HIS202
B	VAL278
B	ARG280
B	LYS285
B	VAL315
B	SER356
B	ILE357
B	LEU362
B	ASP379
B	GLY380
B	MET381
B	ASN382
B	LEU383
B	VAL384
B	GLU387
B	HOH614
B	HOH694
B	HOH712
B	HOH724
B	HOH771
B	HOH774
B	HOH786
B	HOH834

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28743811, ECO:0007744|PDB:5HUU

Chain	Residue	Details
A	TYR89
A	ASP143
A	ARG318
A	LEU383
B	TYR89
B	ASP143
B	ARG318
B	LEU383

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28743811, ECO:0007744|PDB:5HUT

Chain	Residue	Details
A	ARG280
A	LYS285
A	ILE357
A	ASP379
B	ARG280
B	LYS285
B	ILE357
B	ASP379

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