5HT0
Crystal structure of an Antibiotic_NAT family aminoglycoside acetyltransferase HMB0038 from an uncultured soil metagenomic sample in complex with coenzyme A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008080 | molecular_function | N-acetyltransferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
A | 0046677 | biological_process | response to antibiotic |
B | 0008080 | molecular_function | N-acetyltransferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
B | 0046677 | biological_process | response to antibiotic |
C | 0008080 | molecular_function | N-acetyltransferase activity |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
C | 0046677 | biological_process | response to antibiotic |
D | 0008080 | molecular_function | N-acetyltransferase activity |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
D | 0046677 | biological_process | response to antibiotic |
E | 0008080 | molecular_function | N-acetyltransferase activity |
E | 0016746 | molecular_function | acyltransferase activity |
E | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
E | 0046677 | biological_process | response to antibiotic |
F | 0008080 | molecular_function | N-acetyltransferase activity |
F | 0016746 | molecular_function | acyltransferase activity |
F | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
F | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue COA A 301 |
Chain | Residue |
A | HIS29 |
A | GLY96 |
A | PHE97 |
A | PRO160 |
A | THR163 |
A | THR165 |
A | HOH402 |
A | HOH408 |
B | GLN66 |
B | ARG93 |
A | ALA30 |
A | ALA31 |
A | LEU32 |
A | ARG33 |
A | PRO42 |
A | TYR62 |
A | ASP94 |
A | ASN95 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 302 |
Chain | Residue |
A | ASP131 |
A | HOH409 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 303 |
Chain | Residue |
A | ALA133 |
A | LEU134 |
A | ASP135 |
A | ARG141 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 304 |
Chain | Residue |
A | ALA21 |
A | ASP22 |
site_id | AC5 |
Number of Residues | 13 |
Details | binding site for residue COA B 301 |
Chain | Residue |
A | GLN66 |
A | ARG93 |
B | HIS29 |
B | ALA30 |
B | ALA31 |
B | LEU32 |
B | ARG33 |
B | PRO42 |
B | TYR62 |
B | ASN95 |
B | GLY96 |
B | PHE97 |
B | ALA159 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue SO4 B 302 |
Chain | Residue |
B | ASP131 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 303 |
Chain | Residue |
B | ALA133 |
B | LEU134 |
B | ASP135 |
B | ARG141 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 304 |
Chain | Residue |
B | ALA21 |
B | ASP22 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 305 |
Chain | Residue |
B | ARG8 |
F | ARG260 |
site_id | AD1 |
Number of Residues | 1 |
Details | binding site for residue SO4 B 306 |
Chain | Residue |
B | ARG78 |
site_id | AD2 |
Number of Residues | 13 |
Details | binding site for residue COA C 301 |
Chain | Residue |
C | HIS29 |
C | ALA30 |
C | ALA31 |
C | LEU32 |
C | ARG33 |
C | PRO42 |
C | ASN95 |
C | GLY96 |
C | PHE97 |
C | ALA159 |
C | THR163 |
D | GLN66 |
D | ARG93 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 302 |
Chain | Residue |
C | ALA112 |
C | ASP131 |
site_id | AD4 |
Number of Residues | 1 |
Details | binding site for residue SO4 C 303 |
Chain | Residue |
C | ARG8 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 304 |
Chain | Residue |
C | ARG78 |
C | TRP196 |
site_id | AD6 |
Number of Residues | 13 |
Details | binding site for residue COA D 301 |
Chain | Residue |
C | GLN66 |
C | ARG93 |
D | HIS29 |
D | ALA30 |
D | ALA31 |
D | LEU32 |
D | ARG33 |
D | PRO42 |
D | ASN95 |
D | PHE97 |
D | PRO160 |
D | HOH408 |
D | HOH417 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue SO4 D 302 |
Chain | Residue |
D | ASP131 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue SO4 D 303 |
Chain | Residue |
D | ARG8 |
D | HOH411 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue SO4 D 304 |
Chain | Residue |
D | ALA21 |
D | ASP22 |
site_id | AE1 |
Number of Residues | 15 |
Details | binding site for residue COA E 301 |
Chain | Residue |
F | ARG93 |
E | HIS29 |
E | ALA30 |
E | ALA31 |
E | LEU32 |
E | ARG33 |
E | PRO42 |
E | TYR62 |
E | ASN95 |
E | PHE97 |
E | ALA159 |
E | THR163 |
E | THR165 |
E | HOH406 |
F | GLN66 |
site_id | AE2 |
Number of Residues | 2 |
Details | binding site for residue SO4 E 302 |
Chain | Residue |
E | ASP131 |
E | HIS132 |
site_id | AE3 |
Number of Residues | 1 |
Details | binding site for residue SO4 E 303 |
Chain | Residue |
E | ARG8 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue SO4 E 304 |
Chain | Residue |
E | ARG78 |
E | TRP196 |
site_id | AE5 |
Number of Residues | 13 |
Details | binding site for residue COA F 301 |
Chain | Residue |
E | GLN66 |
E | ARG93 |
F | HIS29 |
F | ALA30 |
F | ALA31 |
F | LEU32 |
F | ARG33 |
F | PRO42 |
F | ASN95 |
F | GLY96 |
F | PHE97 |
F | PRO160 |
F | THR163 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue SO4 F 302 |
Chain | Residue |
F | ALA130 |
F | ASP131 |
F | HOH424 |
site_id | AE7 |
Number of Residues | 1 |
Details | binding site for residue SO4 F 303 |
Chain | Residue |
F | ARG197 |
site_id | AE8 |
Number of Residues | 1 |
Details | binding site for residue SO4 F 304 |
Chain | Residue |
F | ARG8 |