5HRV

Crystal structure of the fifth bromodomain of human PB1 in complex with 1-ethylisochromeno[3,4-c]pyrazol-5(2H)-one) compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 64C A 801

Chain	Residue
A	ILE683
A	HOH906
A	HOH944
A	PHE684
A	TYR696
A	MET704
A	ASP705
A	MET731
A	ALA735
A	TYR738
A	ASN739

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site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 802

Chain	Residue
A	ILE683
A	ILE683
A	LEU744
A	ILE745
A	ASP748
A	HOH912
A	HOH927

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY

Chain	Residue	Details
A	SER681-TYR738

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ALA668

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	LEU680

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ILE721

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS670

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LEU685

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