5HR1

Crystal structure of thioredoxin L107A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0015035	molecular_function	protein-disulfide reductase activity
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0045454	biological_process	cell redox homeostasis
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0015035	molecular_function	protein-disulfide reductase activity
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0045454	biological_process	cell redox homeostasis
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0015035	molecular_function	protein-disulfide reductase activity
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0045454	biological_process	cell redox homeostasis
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0015035	molecular_function	protein-disulfide reductase activity
D	0030337	molecular_function	DNA polymerase processivity factor activity
D	0045454	biological_process	cell redox homeostasis
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0015035	molecular_function	protein-disulfide reductase activity
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0045454	biological_process	cell redox homeostasis
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0015035	molecular_function	protein-disulfide reductase activity
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0045454	biological_process	cell redox homeostasis
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0015035	molecular_function	protein-disulfide reductase activity
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CU A 201

Chain	Residue
A	HIS6
B	ASP10
B	HOH332

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CU B 201

Chain	Residue
B	ASP20
D	SER1
D	ASP2

---

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL

Chain	Residue	Details
A	LEU24-LEU42

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---