5HLV

Crystal structure of calcium and zinc-bound human S100A8 in space group P212121

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0002523	biological_process	leukocyte migration involved in inflammatory response
A	0002544	biological_process	chronic inflammatory response
A	0002790	biological_process	peptide secretion
A	0002793	biological_process	positive regulation of peptide secretion
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0008017	molecular_function	microtubule binding
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0014002	biological_process	astrocyte development
A	0016020	cellular_component	membrane
A	0018119	biological_process	peptidyl-cysteine S-nitrosylation
A	0030307	biological_process	positive regulation of cell growth
A	0030593	biological_process	neutrophil chemotaxis
A	0032119	biological_process	sequestering of zinc ion
A	0032496	biological_process	response to lipopolysaccharide
A	0034121	biological_process	regulation of toll-like receptor signaling pathway
A	0034774	cellular_component	secretory granule lumen
A	0035425	biological_process	autocrine signaling
A	0035662	molecular_function	Toll-like receptor 4 binding
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0045111	cellular_component	intermediate filament cytoskeleton
A	0045471	biological_process	response to ethanol
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050544	molecular_function	arachidonic acid binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050786	molecular_function	RAGE receptor binding
A	0050832	biological_process	defense response to fungus
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051493	biological_process	regulation of cytoskeleton organization
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0070488	biological_process	neutrophil aggregation
A	1990660	cellular_component	calprotectin complex
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
B	0002376	biological_process	immune system process
B	0002523	biological_process	leukocyte migration involved in inflammatory response
B	0002544	biological_process	chronic inflammatory response
B	0002790	biological_process	peptide secretion
B	0002793	biological_process	positive regulation of peptide secretion
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006914	biological_process	autophagy
B	0006915	biological_process	apoptotic process
B	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0008017	molecular_function	microtubule binding
B	0008270	molecular_function	zinc ion binding
B	0010043	biological_process	response to zinc ion
B	0014002	biological_process	astrocyte development
B	0016020	cellular_component	membrane
B	0018119	biological_process	peptidyl-cysteine S-nitrosylation
B	0030307	biological_process	positive regulation of cell growth
B	0030593	biological_process	neutrophil chemotaxis
B	0032119	biological_process	sequestering of zinc ion
B	0032496	biological_process	response to lipopolysaccharide
B	0034121	biological_process	regulation of toll-like receptor signaling pathway
B	0034774	cellular_component	secretory granule lumen
B	0035425	biological_process	autocrine signaling
B	0035662	molecular_function	Toll-like receptor 4 binding
B	0042742	biological_process	defense response to bacterium
B	0045087	biological_process	innate immune response
B	0045111	cellular_component	intermediate filament cytoskeleton
B	0045471	biological_process	response to ethanol
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050544	molecular_function	arachidonic acid binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0050786	molecular_function	RAGE receptor binding
B	0050832	biological_process	defense response to fungus
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051493	biological_process	regulation of cytoskeleton organization
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
B	0070488	biological_process	neutrophil aggregation
B	1990660	cellular_component	calprotectin complex
B	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
C	0002376	biological_process	immune system process
C	0002523	biological_process	leukocyte migration involved in inflammatory response
C	0002544	biological_process	chronic inflammatory response
C	0002790	biological_process	peptide secretion
C	0002793	biological_process	positive regulation of peptide secretion
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0008017	molecular_function	microtubule binding
C	0008270	molecular_function	zinc ion binding
C	0010043	biological_process	response to zinc ion
C	0014002	biological_process	astrocyte development
C	0016020	cellular_component	membrane
C	0018119	biological_process	peptidyl-cysteine S-nitrosylation
C	0030307	biological_process	positive regulation of cell growth
C	0030593	biological_process	neutrophil chemotaxis
C	0032119	biological_process	sequestering of zinc ion
C	0032496	biological_process	response to lipopolysaccharide
C	0034121	biological_process	regulation of toll-like receptor signaling pathway
C	0034774	cellular_component	secretory granule lumen
C	0035425	biological_process	autocrine signaling
C	0035662	molecular_function	Toll-like receptor 4 binding
C	0042742	biological_process	defense response to bacterium
C	0045087	biological_process	innate immune response
C	0045111	cellular_component	intermediate filament cytoskeleton
C	0045471	biological_process	response to ethanol
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050544	molecular_function	arachidonic acid binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050786	molecular_function	RAGE receptor binding
C	0050832	biological_process	defense response to fungus
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051493	biological_process	regulation of cytoskeleton organization
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0070488	biological_process	neutrophil aggregation
C	1990660	cellular_component	calprotectin complex
C	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
D	0002376	biological_process	immune system process
D	0002523	biological_process	leukocyte migration involved in inflammatory response
D	0002544	biological_process	chronic inflammatory response
D	0002790	biological_process	peptide secretion
D	0002793	biological_process	positive regulation of peptide secretion
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006914	biological_process	autophagy
D	0006915	biological_process	apoptotic process
D	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0008017	molecular_function	microtubule binding
D	0008270	molecular_function	zinc ion binding
D	0010043	biological_process	response to zinc ion
D	0014002	biological_process	astrocyte development
D	0016020	cellular_component	membrane
D	0018119	biological_process	peptidyl-cysteine S-nitrosylation
D	0030307	biological_process	positive regulation of cell growth
D	0030593	biological_process	neutrophil chemotaxis
D	0032119	biological_process	sequestering of zinc ion
D	0032496	biological_process	response to lipopolysaccharide
D	0034121	biological_process	regulation of toll-like receptor signaling pathway
D	0034774	cellular_component	secretory granule lumen
D	0035425	biological_process	autocrine signaling
D	0035662	molecular_function	Toll-like receptor 4 binding
D	0042742	biological_process	defense response to bacterium
D	0045087	biological_process	innate immune response
D	0045111	cellular_component	intermediate filament cytoskeleton
D	0045471	biological_process	response to ethanol
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050544	molecular_function	arachidonic acid binding
D	0050729	biological_process	positive regulation of inflammatory response
D	0050786	molecular_function	RAGE receptor binding
D	0050832	biological_process	defense response to fungus
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051493	biological_process	regulation of cytoskeleton organization
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070062	cellular_component	extracellular exosome
D	0070488	biological_process	neutrophil aggregation
D	1990660	cellular_component	calprotectin complex
D	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
E	0002376	biological_process	immune system process
E	0002523	biological_process	leukocyte migration involved in inflammatory response
E	0002544	biological_process	chronic inflammatory response
E	0002790	biological_process	peptide secretion
E	0002793	biological_process	positive regulation of peptide secretion
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0008017	molecular_function	microtubule binding
E	0008270	molecular_function	zinc ion binding
E	0010043	biological_process	response to zinc ion
E	0014002	biological_process	astrocyte development
E	0016020	cellular_component	membrane
E	0018119	biological_process	peptidyl-cysteine S-nitrosylation
E	0030307	biological_process	positive regulation of cell growth
E	0030593	biological_process	neutrophil chemotaxis
E	0032119	biological_process	sequestering of zinc ion
E	0032496	biological_process	response to lipopolysaccharide
E	0034121	biological_process	regulation of toll-like receptor signaling pathway
E	0034774	cellular_component	secretory granule lumen
E	0035425	biological_process	autocrine signaling
E	0035662	molecular_function	Toll-like receptor 4 binding
E	0042742	biological_process	defense response to bacterium
E	0045087	biological_process	innate immune response
E	0045111	cellular_component	intermediate filament cytoskeleton
E	0045471	biological_process	response to ethanol
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050544	molecular_function	arachidonic acid binding
E	0050729	biological_process	positive regulation of inflammatory response
E	0050786	molecular_function	RAGE receptor binding
E	0050832	biological_process	defense response to fungus
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051493	biological_process	regulation of cytoskeleton organization
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
E	0070488	biological_process	neutrophil aggregation
E	1990660	cellular_component	calprotectin complex
E	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
F	0002376	biological_process	immune system process
F	0002523	biological_process	leukocyte migration involved in inflammatory response
F	0002544	biological_process	chronic inflammatory response
F	0002790	biological_process	peptide secretion
F	0002793	biological_process	positive regulation of peptide secretion
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0006914	biological_process	autophagy
F	0006915	biological_process	apoptotic process
F	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0008017	molecular_function	microtubule binding
F	0008270	molecular_function	zinc ion binding
F	0010043	biological_process	response to zinc ion
F	0014002	biological_process	astrocyte development
F	0016020	cellular_component	membrane
F	0018119	biological_process	peptidyl-cysteine S-nitrosylation
F	0030307	biological_process	positive regulation of cell growth
F	0030593	biological_process	neutrophil chemotaxis
F	0032119	biological_process	sequestering of zinc ion
F	0032496	biological_process	response to lipopolysaccharide
F	0034121	biological_process	regulation of toll-like receptor signaling pathway
F	0034774	cellular_component	secretory granule lumen
F	0035425	biological_process	autocrine signaling
F	0035662	molecular_function	Toll-like receptor 4 binding
F	0042742	biological_process	defense response to bacterium
F	0045087	biological_process	innate immune response
F	0045111	cellular_component	intermediate filament cytoskeleton
F	0045471	biological_process	response to ethanol
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050544	molecular_function	arachidonic acid binding
F	0050729	biological_process	positive regulation of inflammatory response
F	0050786	molecular_function	RAGE receptor binding
F	0050832	biological_process	defense response to fungus
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051493	biological_process	regulation of cytoskeleton organization
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070062	cellular_component	extracellular exosome
F	0070488	biological_process	neutrophil aggregation
F	1990660	cellular_component	calprotectin complex
F	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
G	0002376	biological_process	immune system process
G	0002523	biological_process	leukocyte migration involved in inflammatory response
G	0002544	biological_process	chronic inflammatory response
G	0002790	biological_process	peptide secretion
G	0002793	biological_process	positive regulation of peptide secretion
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0006914	biological_process	autophagy
G	0006915	biological_process	apoptotic process
G	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0008017	molecular_function	microtubule binding
G	0008270	molecular_function	zinc ion binding
G	0010043	biological_process	response to zinc ion
G	0014002	biological_process	astrocyte development
G	0016020	cellular_component	membrane
G	0018119	biological_process	peptidyl-cysteine S-nitrosylation
G	0030307	biological_process	positive regulation of cell growth
G	0030593	biological_process	neutrophil chemotaxis
G	0032119	biological_process	sequestering of zinc ion
G	0032496	biological_process	response to lipopolysaccharide
G	0034121	biological_process	regulation of toll-like receptor signaling pathway
G	0034774	cellular_component	secretory granule lumen
G	0035425	biological_process	autocrine signaling
G	0035662	molecular_function	Toll-like receptor 4 binding
G	0042742	biological_process	defense response to bacterium
G	0045087	biological_process	innate immune response
G	0045111	cellular_component	intermediate filament cytoskeleton
G	0045471	biological_process	response to ethanol
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050544	molecular_function	arachidonic acid binding
G	0050729	biological_process	positive regulation of inflammatory response
G	0050786	molecular_function	RAGE receptor binding
G	0050832	biological_process	defense response to fungus
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051493	biological_process	regulation of cytoskeleton organization
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome
G	0070488	biological_process	neutrophil aggregation
G	1990660	cellular_component	calprotectin complex
G	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
H	0002376	biological_process	immune system process
H	0002523	biological_process	leukocyte migration involved in inflammatory response
H	0002544	biological_process	chronic inflammatory response
H	0002790	biological_process	peptide secretion
H	0002793	biological_process	positive regulation of peptide secretion
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0006914	biological_process	autophagy
H	0006915	biological_process	apoptotic process
H	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0008017	molecular_function	microtubule binding
H	0008270	molecular_function	zinc ion binding
H	0010043	biological_process	response to zinc ion
H	0014002	biological_process	astrocyte development
H	0016020	cellular_component	membrane
H	0018119	biological_process	peptidyl-cysteine S-nitrosylation
H	0030307	biological_process	positive regulation of cell growth
H	0030593	biological_process	neutrophil chemotaxis
H	0032119	biological_process	sequestering of zinc ion
H	0032496	biological_process	response to lipopolysaccharide
H	0034121	biological_process	regulation of toll-like receptor signaling pathway
H	0034774	cellular_component	secretory granule lumen
H	0035425	biological_process	autocrine signaling
H	0035662	molecular_function	Toll-like receptor 4 binding
H	0042742	biological_process	defense response to bacterium
H	0045087	biological_process	innate immune response
H	0045111	cellular_component	intermediate filament cytoskeleton
H	0045471	biological_process	response to ethanol
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050544	molecular_function	arachidonic acid binding
H	0050729	biological_process	positive regulation of inflammatory response
H	0050786	molecular_function	RAGE receptor binding
H	0050832	biological_process	defense response to fungus
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051493	biological_process	regulation of cytoskeleton organization
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070062	cellular_component	extracellular exosome
H	0070488	biological_process	neutrophil aggregation
H	1990660	cellular_component	calprotectin complex
H	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 101

Chain	Residue
A	SER20
A	LYS23
A	ASN25
A	ALA28
A	TYR30
A	HOH215

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 102

Chain	Residue
A	ALA65
A	GLU70
A	HOH210
A	ASP59
A	ASN61
A	ASP63

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 103

Chain	Residue
A	HIS17
A	HIS27
D	HIS83
D	HIS87

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 104

Chain	Residue
A	HIS83
A	HIS87
D	HIS17
D	HIS27

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ACT A 105

Chain	Residue
A	ASN61
A	ASN67
A	GLU70
C	ILE76

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA B 101

Chain	Residue
B	SER20
B	LYS23
B	ASN25
B	ALA28
B	TYR30
B	HOH209

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA B 102

Chain	Residue
B	ASP59
B	ASN61
B	ASP63
B	ALA65
B	GLU70
B	HOH210

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 103

Chain	Residue
B	HIS83
B	HIS87
H	HIS17
H	HIS27

---

site_id	AC9
Number of Residues	6
Details	binding site for residue ACT B 104

Chain	Residue
B	ILE60
B	ASN61
B	ASN67
B	GLU70
B	HOH210
G	ILE76

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 105

Chain	Residue
B	HIS17
H	HIS83
H	HIS87
H	CL103

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA C 101

Chain	Residue
C	SER20
C	LYS23
C	ASN25
C	ALA28
C	TYR30
C	HOH215

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA C 102

Chain	Residue
C	ASP59
C	ASN61
C	ASP63
C	ALA65
C	GLU70
C	HOH214

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN C 103

Chain	Residue
C	HIS17
C	HIS27
E	HIS83
E	HIS87

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 104

Chain	Residue
C	HIS83
C	HIS87
E	HIS17
E	HIS27

---

site_id	AD6
Number of Residues	5
Details	binding site for residue ACT C 105

Chain	Residue
A	ILE76
C	ASN61
C	ASN67
C	GLU70
C	HOH214

---

site_id	AD7
Number of Residues	3
Details	binding site for residue ACT C 106

Chain	Residue
C	TYR30
D	ASN61
D	THR62

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA D 101

Chain	Residue
D	SER20
D	LYS23
D	ASN25
D	ALA28
D	HOH215

---

site_id	AD9
Number of Residues	6
Details	binding site for residue CA D 102

Chain	Residue
D	ASP59
D	ASN61
D	ASP63
D	ALA65
D	GLU70
D	HOH216

---

site_id	AE1
Number of Residues	3
Details	binding site for residue ACT D 103

Chain	Residue
A	PRO43
D	THR3
D	GLU6

---

site_id	AE2
Number of Residues	5
Details	binding site for residue CA E 101

Chain	Residue
E	SER20
E	LYS23
E	ASN25
E	ALA28
E	HOH205

---

site_id	AE3
Number of Residues	6
Details	binding site for residue CA E 102

Chain	Residue
E	ASP63
E	ALA65
E	GLU70
E	HOH209
E	ASP59
E	ASN61

---

site_id	AE4
Number of Residues	6
Details	binding site for residue CA F 101

Chain	Residue
F	SER20
F	LYS23
F	ASN25
F	ALA28
F	TYR30
F	HOH206

---

site_id	AE5
Number of Residues	6
Details	binding site for residue CA F 102

Chain	Residue
F	ASP59
F	ASN61
F	ASP63
F	ALA65
F	GLU70
F	HOH202

---

site_id	AE6
Number of Residues	4
Details	binding site for residue ZN F 103

Chain	Residue
F	HIS17
F	HIS27
G	HIS83
G	HIS87

---

site_id	AE7
Number of Residues	4
Details	binding site for residue ZN F 104

Chain	Residue
F	HIS83
F	HIS87
F	CL105
G	HIS17

---

site_id	AE8
Number of Residues	4
Details	binding site for residue CL F 105

Chain	Residue
F	HIS83
F	HIS87
F	ZN104
G	HIS27

---

site_id	AE9
Number of Residues	6
Details	binding site for residue CA G 101

Chain	Residue
G	SER20
G	LYS23
G	ASN25
G	ALA28
G	TYR30
G	HOH210

---

site_id	AF1
Number of Residues	6
Details	binding site for residue CA G 102

Chain	Residue
G	ASP59
G	ASN61
G	ASP63
G	ALA65
G	GLU70
G	HOH207

---

site_id	AF2
Number of Residues	5
Details	binding site for residue ACT G 103

Chain	Residue
B	ILE76
G	ILE60
G	ASN61
G	ASN67
G	GLU70

---

site_id	AF3
Number of Residues	5
Details	binding site for residue CA H 101

Chain	Residue
H	SER20
H	LYS23
H	ASN25
H	ALA28
H	HOH310

---

site_id	AF4
Number of Residues	6
Details	binding site for residue CA H 102

Chain	Residue
H	ASP59
H	ASN61
H	ASP63
H	ALA65
H	GLU70
H	HOH308

---

site_id	AF5
Number of Residues	5
Details	binding site for residue CL H 103

Chain	Residue
B	HIS17
B	HIS27
B	ZN105
H	HIS83
H	HIS87

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DINTDGAVNfqEF

Chain	Residue	Details
A	ASP59-PHE71

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. WFkeLDintDgavNFqEFliLV

Chain	Residue	Details
A	TRP54-VAL75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	HIS17
B	HIS87
C	HIS17
C	HIS27
C	ASP33
C	HIS83
C	HIS87
D	HIS17
D	HIS27
D	ASP33
D	HIS83
A	HIS27
D	HIS87
E	HIS17
E	HIS27
E	ASP33
E	HIS83
E	HIS87
F	HIS17
F	HIS27
F	ASP33
F	HIS83
A	ASP33
F	HIS87
G	HIS17
G	HIS27
G	ASP33
G	HIS83
G	HIS87
H	HIS17
H	HIS27
H	ASP33
H	HIS83
A	HIS83
H	HIS87
A	HIS87
B	HIS17
B	HIS27
B	ASP33
B	HIS83

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	ASP59
C	ASN61
C	ASP63
C	GLU70
D	ASP59
D	ASN61
D	ASP63
D	GLU70
E	ASP59
E	ASN61
E	ASP63
A	ASN61
E	GLU70
F	ASP59
F	ASN61
F	ASP63
F	GLU70
G	ASP59
G	ASN61
G	ASP63
G	GLU70
H	ASP59
A	ASP63
H	ASN61
H	ASP63
H	GLU70
A	GLU70
B	ASP59
B	ASN61
B	ASP63
B	GLU70
C	ASP59

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:18832721

Chain	Residue	Details
A	CYS42
B	CYS42
C	CYS42
D	CYS42
E	CYS42
F	CYS42
G	CYS42
H	CYS42

---