Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HK2

Human sigma-1 receptor bound to 4-IBP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004985	molecular_function	G protein-coupled opioid receptor activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0007399	biological_process	nervous system development
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0019371	biological_process	cyclooxygenase pathway
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0031410	cellular_component	cytoplasmic vesicle
A	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
A	0038023	molecular_function	signaling receptor activity
A	0043025	cellular_component	neuronal cell body
A	0043523	biological_process	regulation of neuron apoptotic process
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
A	0070161	cellular_component	anchoring junction
A	0070207	biological_process	protein homotrimerization
A	0097305	biological_process	response to alcohol
A	0098794	cellular_component	postsynapse
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
A	1904313	biological_process	response to methamphetamine hydrochloride
A	1904751	biological_process	positive regulation of protein localization to nucleolus
A	1990708	biological_process	conditioned place preference
B	0001516	biological_process	prostaglandin biosynthetic process
B	0004985	molecular_function	G protein-coupled opioid receptor activity
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0007399	biological_process	nervous system development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0019371	biological_process	cyclooxygenase pathway
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0031410	cellular_component	cytoplasmic vesicle
B	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
B	0038023	molecular_function	signaling receptor activity
B	0043025	cellular_component	neuronal cell body
B	0043523	biological_process	regulation of neuron apoptotic process
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
B	0070161	cellular_component	anchoring junction
B	0070207	biological_process	protein homotrimerization
B	0097305	biological_process	response to alcohol
B	0098794	cellular_component	postsynapse
B	0098839	cellular_component	postsynaptic density membrane
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
B	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
B	1904313	biological_process	response to methamphetamine hydrochloride
B	1904751	biological_process	positive regulation of protein localization to nucleolus
B	1990708	biological_process	conditioned place preference
C	0001516	biological_process	prostaglandin biosynthetic process
C	0004985	molecular_function	G protein-coupled opioid receptor activity
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005637	cellular_component	nuclear inner membrane
C	0005640	cellular_component	nuclear outer membrane
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0007399	biological_process	nervous system development
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0019371	biological_process	cyclooxygenase pathway
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0031410	cellular_component	cytoplasmic vesicle
C	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
C	0038023	molecular_function	signaling receptor activity
C	0043025	cellular_component	neuronal cell body
C	0043523	biological_process	regulation of neuron apoptotic process
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
C	0070161	cellular_component	anchoring junction
C	0070207	biological_process	protein homotrimerization
C	0097305	biological_process	response to alcohol
C	0098794	cellular_component	postsynapse
C	0098839	cellular_component	postsynaptic density membrane
C	0098978	cellular_component	glutamatergic synapse
C	0150052	biological_process	regulation of postsynapse assembly
C	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
C	1904313	biological_process	response to methamphetamine hydrochloride
C	1904751	biological_process	positive regulation of protein localization to nucleolus
C	1990708	biological_process	conditioned place preference

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 61V A 301

Chain	Residue
A	VAL84
A	MET93
A	PHE107
A	SER117
A	TYR120
A	ASP126
A	GLU172
A	TYR206

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG208
A	ARG211
A	ARG204

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	PHE37
A	GLN38
A	ARG39
A	ARG175

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 304

Chain	Residue
A	LEU52
A	ASP53
A	HIS54
A	SER130
A	ASN167

site_id	AC5
Number of Residues	10
Details	binding site for residue 61V B 301

Chain	Residue
B	VAL78
B	TRP83
B	MET87
B	PHE101
B	TYR114
B	ASP120
B	GLU166
B	LEU176
B	ALA179
B	TYR200

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG202
B	ARG205
B	SO4305

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 B 303

Chain	Residue
B	TYR195
B	ARG198
B	ARG198
B	SO4305

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
A	ARG114
B	ARG108
C	ARG114

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 B 305

Chain	Residue
B	PHE194
B	ARG198
B	SO4302
B	SO4303

site_id	AD1
Number of Residues	2
Details	binding site for residue OLC B 306

Chain	Residue
B	GLU207
C	TRP27

site_id	AD2
Number of Residues	3
Details	binding site for residue OLC B 307

Chain	Residue
B	TRP23
B	GLN27
C	TRP27

site_id	AD3
Number of Residues	4
Details	binding site for residue OLC B 308

Chain	Residue
B	LEU94
B	SER95
B	GLY170
B	OLC309

site_id	AD4
Number of Residues	4
Details	binding site for residue OLC B 309

Chain	Residue
B	TRP115
B	GLU117
B	GLY170
B	OLC308

site_id	AD5
Number of Residues	3
Details	binding site for residue OLC B 310

Chain	Residue
B	GLU49
B	LEU73
B	TRP75

site_id	AD6
Number of Residues	12
Details	binding site for residue 61V C 301

Chain	Residue
C	VAL84
C	TRP89
C	MET93
C	PHE107
C	SER117
C	TYR120
C	ILE124
C	ASP126
C	GLU172
C	THR181
C	ALA185
C	TYR206

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 C 302

Chain	Residue
C	GLU78
C	ARG208
C	ARG211

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 C 303

Chain	Residue
C	GLN38
C	ARG39
C	ARG175

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 C 304

Chain	Residue
C	ASP53
C	HIS54
C	ASN167

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 C 305

Chain	Residue
B	SER124
B	GLY125
B	PRO142
C	ARG60

site_id	AE2
Number of Residues	1
Details	binding site for residue SO4 C 306

Chain	Residue
C	ARG204

site_id	AE3
Number of Residues	6
Details	binding site for residue OLC C 307

Chain	Residue
B	THR209
C	TRP121
C	ALA122
C	GLU123
C	ARG175
C	GLY176

site_id	AE4
Number of Residues	1
Details	binding site for residue OLC C 308

Chain	Residue
B	GLU144

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27042935","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Targeting to endoplasmic reticulum-associated lipid droplets","evidences":[{"source":"UniProtKB","id":"O55242","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Important for ligand-binding","evidences":[{"source":"UniProtKB","id":"Q60492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Important for ligand binding","evidences":[{"source":"PubMed","id":"11476895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)