5HI0

The Substrate Binding Mode and Chemical Basis of a Reaction Specificity Switch in Oxalate Decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0033609	biological_process	oxalate metabolic process
A	0046564	molecular_function	oxalate decarboxylase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CO A 401

Chain	Residue
A	HIS95
A	HIS97
A	GLU101
A	HIS140
A	OXL403
A	HOH516

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site_id	AC2
Number of Residues	7
Details	binding site for residue CO A 402

Chain	Residue
A	HIS318
A	GLU332
A	HOH503
A	HOH524
A	HIS272
A	HIS274
A	GLU279

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site_id	AC3
Number of Residues	11
Details	binding site for residue OXL A 403

Chain	Residue
A	MET84
A	ARG92
A	HIS95
A	HIS97
A	GLU101
A	HIS140
A	LEU153
A	THR164
A	CO401
A	HOH513
A	HOH516

---

site_id	AC4
Number of Residues	1
Details	binding site for residue NA A 404

Chain	Residue
A	HOH543

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	141
Details	Domain: {"description":"Cupin type-1 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"12056897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12056897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 231

Chain	Residue	Details
A	ARG92	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor
A	HIS95	metal ligand
A	HIS97	metal ligand
A	GLU101	metal ligand
A	HIS140	metal ligand

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