Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5HFJ

crystal structure of M1.HpyAVI-SAM complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0005737	cellular_component	cytoplasm
A	0008168	molecular_function	methyltransferase activity
A	0008170	molecular_function	N-methyltransferase activity
A	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0005737	cellular_component	cytoplasm
B	0008168	molecular_function	methyltransferase activity
B	0008170	molecular_function	N-methyltransferase activity
B	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0005737	cellular_component	cytoplasm
C	0008168	molecular_function	methyltransferase activity
C	0008170	molecular_function	N-methyltransferase activity
C	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
C	0016740	molecular_function	transferase activity
C	0032259	biological_process	methylation
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0005737	cellular_component	cytoplasm
D	0008168	molecular_function	methyltransferase activity
D	0008170	molecular_function	N-methyltransferase activity
D	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
D	0016740	molecular_function	transferase activity
D	0032259	biological_process	methylation
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0005737	cellular_component	cytoplasm
E	0008168	molecular_function	methyltransferase activity
E	0008170	molecular_function	N-methyltransferase activity
E	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
E	0016740	molecular_function	transferase activity
E	0032259	biological_process	methylation
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0005737	cellular_component	cytoplasm
F	0008168	molecular_function	methyltransferase activity
F	0008170	molecular_function	N-methyltransferase activity
F	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
F	0016740	molecular_function	transferase activity
F	0032259	biological_process	methylation
G	0003676	molecular_function	nucleic acid binding
G	0003677	molecular_function	DNA binding
G	0005737	cellular_component	cytoplasm
G	0008168	molecular_function	methyltransferase activity
G	0008170	molecular_function	N-methyltransferase activity
G	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
G	0016740	molecular_function	transferase activity
G	0032259	biological_process	methylation
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0005737	cellular_component	cytoplasm
H	0008168	molecular_function	methyltransferase activity
H	0008170	molecular_function	N-methyltransferase activity
H	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
H	0016740	molecular_function	transferase activity
H	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue SAM A 301

Chain	Residue
A	ASP8
A	MET196
A	GLY197
A	SER198
A	THR200
A	GLU216
A	SER217
A	GLU218
A	TYR221
A	ALA9
A	ASP29
A	PRO30
A	LYS165
A	LYS167
A	HIS168
A	PRO194
A	PHE195

site_id	AC2
Number of Residues	18
Details	binding site for residue SAM B 301

Chain	Residue
B	ALA7
B	ASP8
B	ALA9
B	ASP29
B	PRO30
B	HIS168
B	THR170
B	GLN171
B	LYS172
B	PRO194
B	PHE195
B	MET196
B	GLY197
B	SER198
B	GLY199
B	GLU216
B	SER217
B	TYR221

site_id	AC3
Number of Residues	19
Details	binding site for residue SAM C 301

Chain	Residue
C	ASP8
C	ALA9
C	ASP29
C	PRO31
C	HIS168
C	THR170
C	GLN171
C	LYS172
C	PRO194
C	PHE195
C	MET196
C	GLY197
C	SER198
C	GLY199
C	THR200
C	GLU216
C	SER217
C	GLU218
C	TYR221

site_id	AC4
Number of Residues	13
Details	binding site for residue SAM D 301

Chain	Residue
D	ALA7
D	ASP8
D	ALA9
D	ASP29
D	PRO31
D	PHE195
D	MET196
D	GLY197
D	SER198
D	GLU216
D	SER217
D	GLU218
D	TYR221

site_id	AC5
Number of Residues	12
Details	binding site for residue SAM E 301

Chain	Residue
E	ASP8
E	ALA9
E	ASP29
E	PRO169
E	LYS172
E	PHE195
E	GLY197
E	SER198
E	GLY199
E	THR200
E	GLU216
E	SER217

site_id	AC6
Number of Residues	15
Details	binding site for residue SAM F 301

Chain	Residue
F	ASP8
F	ALA9
F	ASP29
F	PRO31
F	THR170
F	GLN171
F	LYS172
F	PRO194
F	PHE195
F	MET196
F	GLY197
F	SER198
F	GLU216
F	SER217
F	TYR221

site_id	AC7
Number of Residues	17
Details	binding site for residue SAM G 301

Chain	Residue
G	THR170
G	LYS172
G	PHE195
G	MET196
G	GLY197
G	SER198
G	GLY199
G	THR200
G	GLU216
G	SER217
G	GLU218
G	TYR221
G	ALA7
G	ASP8
G	ALA9
G	ASP29
G	HIS168

site_id	AC8
Number of Residues	17
Details	binding site for residue SAM H 301

Chain	Residue
H	ALA7
H	ASP8
H	ALA9
H	ASP29
H	PRO31
H	THR170
H	GLN171
H	PRO194
H	PHE195
H	MET196
H	GLY197
H	SER198
H	GLY199
H	THR200
H	GLU216
H	SER217
H	TYR221

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. IITDPPY

Chain	Residue	Details
A	ILE26-TYR32

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)