5HEN

Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 201

Chain	Residue
A	TYR113
A	ASN156
A	ILE162
A	HOH304

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO B 201

Chain	Residue
B	TYR113
B	ASN156
B	HOH310

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO C 201

Chain	Residue
C	ASN156
C	HOH302

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFlqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6

Chain	Residue	Details
A	ASP112
C	TYR155
C	ASN156
C	LYS157
A	TYR155
A	ASN156
A	LYS157
B	ASP112
B	TYR155
B	ASN156
B	LYS157
C	ASP112

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20048151, ECO:0007744|PDB:2DVQ, ECO:0007744|PDB:2DVS

Chain	Residue	Details
A	ASP160
A	ASP161
B	ASP160
B	ASP161
C	ASP160
C	ASP161

---