Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue TLA A 501 |
| Chain | Residue |
| A | ARG68 |
| A | ASN89 |
| A | HIS110 |
| A | ARG111 |
| A | ASN175 |
| A | HOH607 |
| A | HOH699 |
| A | HOH853 |
| A | HOH922 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 60S A 502 |
| Chain | Residue |
| A | LEU91 |
| A | ASP93 |
| A | SER96 |
| A | ASN98 |
| A | VAL130 |
| A | TYR132 |
| A | TRP176 |
| A | ILE187 |
| A | ARG189 |
| A | ASP289 |
| A | GLY291 |
| A | THR292 |
| A | HOH665 |
| A | HOH697 |
| A | HOH855 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue TLA B 501 |
| Chain | Residue |
| B | ARG68 |
| B | ASN89 |
| B | HIS110 |
| B | ARG111 |
| B | ASN175 |
| B | HOH609 |
| B | HOH766 |
| B | HOH817 |
| B | HOH855 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 60S B 502 |
| Chain | Residue |
| B | LEU91 |
| B | ASP93 |
| B | SER96 |
| B | ASN98 |
| B | VAL130 |
| B | TYR132 |
| B | ILE171 |
| B | TRP176 |
| B | ILE187 |
| B | ARG189 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | HOH692 |
| B | HOH744 |
| B | HOH819 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP93 | |
| A | ASP289 | |
| B | ASP93 | |
| B | ASP289 | |
| Chain | Residue | Details |
| A | LYS126 | |
| B | LYS279 | |
| B | LYS285 | |
| B | LYS299 | |
| B | LYS300 | |
| B | LYS307 | |
| A | LYS275 | |
| A | LYS279 | |
| A | LYS285 | |
| A | LYS299 | |
| A | LYS300 | |
| A | LYS307 | |
| B | LYS126 | |
| B | LYS275 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN153 | |
| A | ASN172 | |
| A | ASN223 | |
| A | ASN354 | |
| B | ASN153 | |
| B | ASN172 | |
| B | ASN223 | |
| B | ASN354 | |
