Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0016020 | cellular_component | membrane |
B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue TLA A 501 |
Chain | Residue |
A | ARG68 |
A | ASN89 |
A | HIS110 |
A | ARG111 |
A | ASN175 |
A | HOH601 |
A | HOH736 |
A | HOH789 |
A | HOH840 |
site_id | AC2 |
Number of Residues | 19 |
Details | binding site for residue 60Y A 502 |
Chain | Residue |
A | SER71 |
A | GLN73 |
A | GLY74 |
A | LEU91 |
A | ASP93 |
A | SER96 |
A | VAL130 |
A | TYR132 |
A | PHE169 |
A | ILE171 |
A | ILE187 |
A | ARG189 |
A | ASP289 |
A | GLY291 |
A | THR292 |
A | THR293 |
A | HOH756 |
A | HOH770 |
A | HOH788 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue TLA B 501 |
Chain | Residue |
B | ARG68 |
B | ASN89 |
B | HIS110 |
B | ARG111 |
B | ASN175 |
B | HOH608 |
B | HOH638 |
B | HOH773 |
B | HOH829 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue 60Y B 502 |
Chain | Residue |
B | SER71 |
B | GLN73 |
B | GLY74 |
B | LEU91 |
B | ASP93 |
B | SER96 |
B | VAL130 |
B | TYR132 |
B | PHE169 |
B | ILE171 |
B | TRP176 |
B | ILE187 |
B | ARG189 |
B | ASP289 |
B | SER290 |
B | GLY291 |
B | THR292 |
B | THR293 |
B | HOH661 |
B | HOH751 |
B | HOH790 |
B | HOH893 |
Functional Information from PROSITE/UniProt
site_id | PS00141 |
Number of Residues | 12 |
Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
Chain | Residue | Details |
A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP93 | |
A | ASP289 | |
B | ASP93 | |
B | ASP289 | |
Chain | Residue | Details |
A | LYS126 | |
B | LYS279 | |
B | LYS285 | |
B | LYS299 | |
B | LYS300 | |
B | LYS307 | |
A | LYS275 | |
A | LYS279 | |
A | LYS285 | |
A | LYS299 | |
A | LYS300 | |
A | LYS307 | |
B | LYS126 | |
B | LYS275 | |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN153 | |
A | ASN172 | |
A | ASN223 | |
A | ASN354 | |
B | ASN153 | |
B | ASN172 | |
B | ASN223 | |
B | ASN354 | |