5H9U

Crystal structure of a thermostable methionine adenosyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004478	molecular_function	methionine adenosyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY

Chain	Residue	Details
C	GLY127-TYR137

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site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
C	GLY271-ASP279

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00086

Chain	Residue	Details
C	HIS16
A	GLN100
A	ASP175
A	ARG242
A	ARG257
A	LYS282
B	HIS16
B	GLU57
B	GLN100
B	ASP175
B	ARG242
C	GLU57
B	ARG257
B	LYS282
D	HIS16
D	GLU57
D	GLN100
D	ASP175
D	ARG242
D	ARG257
D	LYS282
C	GLN100
C	ASP175
C	ARG242
C	ARG257
C	LYS282
A	HIS16
A	GLU57

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site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00086

Chain	Residue	Details
C	ASP18
A	LYS278
B	ASP18
B	GLU44
B	ASP251
B	ALA274
B	LYS278
D	ASP18
D	GLU44
D	ASP251
D	ALA274
C	GLU44
D	LYS278
C	ASP251
C	ALA274
C	LYS278
A	ASP18
A	GLU44
A	ASP251
A	ALA274

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