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5H64

Cryo-EM structure of mTORC1

Functional Information from GO Data
ChainGOidnamespacecontents
a0000139cellular_componentGolgi membrane
a0000166molecular_functionnucleotide binding
a0000822molecular_functioninositol hexakisphosphate binding
a0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
a0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
a0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
a0001156molecular_functionTFIIIC-class transcription factor complex binding
a0001558biological_processregulation of cell growth
a0002296biological_processT-helper 1 cell lineage commitment
a0004672molecular_functionprotein kinase activity
a0004674molecular_functionprotein serine/threonine kinase activity
a0004713molecular_functionprotein tyrosine kinase activity
a0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
a0005515molecular_functionprotein binding
a0005524molecular_functionATP binding
a0005634cellular_componentnucleus
a0005635cellular_componentnuclear envelope
a0005654cellular_componentnucleoplasm
a0005737cellular_componentcytoplasm
a0005741cellular_componentmitochondrial outer membrane
a0005764cellular_componentlysosome
a0005765cellular_componentlysosomal membrane
a0005783cellular_componentendoplasmic reticulum
a0005789cellular_componentendoplasmic reticulum membrane
a0005794cellular_componentGolgi apparatus
a0005829cellular_componentcytosol
a0005886cellular_componentplasma membrane
a0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
a0006468biological_processprotein phosphorylation
a0006954biological_processinflammatory response
a0006974biological_processDNA damage response
a0007010biological_processcytoskeleton organization
a0008361biological_processregulation of cell size
a0009267biological_processcellular response to starvation
a0009408biological_processresponse to heat
a0009891biological_processpositive regulation of biosynthetic process
a0010506biological_processregulation of autophagy
a0010507biological_processnegative regulation of autophagy
a0010718biological_processpositive regulation of epithelial to mesenchymal transition
a0012505cellular_componentendomembrane system
a0016020cellular_componentmembrane
a0016241biological_processregulation of macroautophagy
a0016242biological_processnegative regulation of macroautophagy
a0016301molecular_functionkinase activity
a0016605cellular_componentPML body
a0016740molecular_functiontransferase activity
a0019216biological_processregulation of lipid metabolic process
a0019228biological_processneuronal action potential
a0030307biological_processpositive regulation of cell growth
a0030425cellular_componentdendrite
a0031295biological_processT cell costimulation
a0031410cellular_componentcytoplasmic vesicle
a0031667biological_processresponse to nutrient levels
a0031669biological_processcellular response to nutrient levels
a0031670biological_processcellular response to nutrient
a0031929biological_processTOR signaling
a0031931cellular_componentTORC1 complex
a0031932cellular_componentTORC2 complex
a0032869biological_processcellular response to insulin stimulus
a0032956biological_processregulation of actin cytoskeleton organization
a0034198biological_processcellular response to amino acid starvation
a0038202biological_processTORC1 signaling
a0038203biological_processTORC2 signaling
a0042752biological_processregulation of circadian rhythm
a0042802molecular_functionidentical protein binding
a0043022molecular_functionribosome binding
a0043066biological_processnegative regulation of apoptotic process
a0043200biological_processresponse to amino acid
a0043276biological_processanoikis
a0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
a0044325molecular_functiontransmembrane transporter binding
a0044877molecular_functionprotein-containing complex binding
a0045335cellular_componentphagocytic vesicle
a0045597biological_processpositive regulation of cell differentiation
a0045670biological_processregulation of osteoclast differentiation
a0045727biological_processpositive regulation of translation
a0045821biological_processpositive regulation of glycolytic process
a0045860biological_processpositive regulation of protein kinase activity
a0045945biological_processpositive regulation of transcription by RNA polymerase III
a0045948biological_processpositive regulation of translational initiation
a0046627biological_processnegative regulation of insulin receptor signaling pathway
a0046889biological_processpositive regulation of lipid biosynthetic process
a0048266biological_processbehavioral response to pain
a0050821biological_processprotein stabilization
a0051219molecular_functionphosphoprotein binding
a0051240biological_processpositive regulation of multicellular organismal process
a0051549biological_processpositive regulation of keratinocyte migration
a0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
a0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
a0055006biological_processcardiac cell development
a0061431biological_processcellular response to methionine
a0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
a0071230biological_processcellular response to amino acid stimulus
a0071233biological_processcellular response to L-leucine
a0071456biological_processcellular response to hypoxia
a0071470biological_processcellular response to osmotic stress
a0080135biological_processregulation of cellular response to stress
a0097700biological_processvascular endothelial cell response to laminar fluid shear stress
a0106310molecular_functionprotein serine kinase activity
a1900034biological_processregulation of cellular response to heat
a1900181biological_processnegative regulation of protein localization to nucleus
a1901796biological_processregulation of signal transduction by p53 class mediator
a1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
a1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
a1904059biological_processregulation of locomotor rhythm
a1904690biological_processpositive regulation of cytoplasmic translational initiation
a1905671biological_processregulation of lysosome organization
a1905672biological_processnegative regulation of lysosome organization
a1905857biological_processpositive regulation of pentose-phosphate shunt
a1990253biological_processcellular response to leucine starvation
a2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
a2000785biological_processregulation of autophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000822molecular_functioninositol hexakisphosphate binding
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0002296biological_processT-helper 1 cell lineage commitment
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009891biological_processpositive regulation of biosynthetic process
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0019216biological_processregulation of lipid metabolic process
A0019228biological_processneuronal action potential
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0034198biological_processcellular response to amino acid starvation
A0038202biological_processTORC1 signaling
A0038203biological_processTORC2 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045597biological_processpositive regulation of cell differentiation
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045821biological_processpositive regulation of glycolytic process
A0045860biological_processpositive regulation of protein kinase activity
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045948biological_processpositive regulation of translational initiation
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0050821biological_processprotein stabilization
A0051219molecular_functionphosphoprotein binding
A0051240biological_processpositive regulation of multicellular organismal process
A0051549biological_processpositive regulation of keratinocyte migration
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0061431biological_processcellular response to methionine
A0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0097700biological_processvascular endothelial cell response to laminar fluid shear stress
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1904059biological_processregulation of locomotor rhythm
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905671biological_processregulation of lysosome organization
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
A2000785biological_processregulation of autophagosome assembly
b0001558biological_processregulation of cell growth
b0001938biological_processpositive regulation of endothelial cell proliferation
b0004674molecular_functionprotein serine/threonine kinase activity
b0005515molecular_functionprotein binding
b0005654cellular_componentnucleoplasm
b0005737cellular_componentcytoplasm
b0005764cellular_componentlysosome
b0005765cellular_componentlysosomal membrane
b0005829cellular_componentcytosol
b0006974biological_processDNA damage response
b0008361biological_processregulation of cell size
b0009267biological_processcellular response to starvation
b0009410biological_processresponse to xenobiotic stimulus
b0010494cellular_componentcytoplasmic stress granule
b0010506biological_processregulation of autophagy
b0010507biological_processnegative regulation of autophagy
b0010646biological_processregulation of cell communication
b0019901molecular_functionprotein kinase binding
b0023051biological_processregulation of signaling
b0030291molecular_functionprotein serine/threonine kinase inhibitor activity
b0030295molecular_functionprotein kinase activator activity
b0030307biological_processpositive regulation of cell growth
b0030425cellular_componentdendrite
b0030674molecular_functionprotein-macromolecule adaptor activity
b0031267molecular_functionsmall GTPase binding
b0031669biological_processcellular response to nutrient levels
b0031929biological_processTOR signaling
b0031931cellular_componentTORC1 complex
b0032008biological_processpositive regulation of TOR signaling
b0035176biological_processsocial behavior
b0038202biological_processTORC1 signaling
b0043025cellular_componentneuronal cell body
b0044877molecular_functionprotein-containing complex binding
b0045672biological_processpositive regulation of osteoclast differentiation
b0045821biological_processpositive regulation of glycolytic process
b0045945biological_processpositive regulation of transcription by RNA polymerase III
b0046889biological_processpositive regulation of lipid biosynthetic process
b0060255biological_processregulation of macromolecule metabolic process
b0071230biological_processcellular response to amino acid stimulus
b0071233biological_processcellular response to L-leucine
b0071333biological_processcellular response to glucose stimulus
b0071456biological_processcellular response to hypoxia
b0071470biological_processcellular response to osmotic stress
b0071889molecular_function14-3-3 protein binding
b0080090biological_processregulation of primary metabolic process
b0140767molecular_functionenzyme-substrate adaptor activity
b1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
b1901331biological_processpositive regulation of odontoblast differentiation
b1905857biological_processpositive regulation of pentose-phosphate shunt
B0001558biological_processregulation of cell growth
B0001938biological_processpositive regulation of endothelial cell proliferation
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006974biological_processDNA damage response
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009410biological_processresponse to xenobiotic stimulus
B0010494cellular_componentcytoplasmic stress granule
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010646biological_processregulation of cell communication
B0019901molecular_functionprotein kinase binding
B0023051biological_processregulation of signaling
B0030291molecular_functionprotein serine/threonine kinase inhibitor activity
B0030295molecular_functionprotein kinase activator activity
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031267molecular_functionsmall GTPase binding
B0031669biological_processcellular response to nutrient levels
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0032008biological_processpositive regulation of TOR signaling
B0035176biological_processsocial behavior
B0038202biological_processTORC1 signaling
B0043025cellular_componentneuronal cell body
B0044877molecular_functionprotein-containing complex binding
B0045672biological_processpositive regulation of osteoclast differentiation
B0045821biological_processpositive regulation of glycolytic process
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0046889biological_processpositive regulation of lipid biosynthetic process
B0060255biological_processregulation of macromolecule metabolic process
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071333biological_processcellular response to glucose stimulus
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0071889molecular_function14-3-3 protein binding
B0080090biological_processregulation of primary metabolic process
B0140767molecular_functionenzyme-substrate adaptor activity
B1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
B1901331biological_processpositive regulation of odontoblast differentiation
B1905857biological_processpositive regulation of pentose-phosphate shunt
c0004674molecular_functionprotein serine/threonine kinase activity
c0005515molecular_functionprotein binding
c0005654cellular_componentnucleoplasm
c0005737cellular_componentcytoplasm
c0005765cellular_componentlysosomal membrane
c0005829cellular_componentcytosol
c0006974biological_processDNA damage response
c0007010biological_processcytoskeleton organization
c0010507biological_processnegative regulation of autophagy
c0030307biological_processpositive regulation of cell growth
c0030674molecular_functionprotein-macromolecule adaptor activity
c0031669biological_processcellular response to nutrient levels
c0031929biological_processTOR signaling
c0031931cellular_componentTORC1 complex
c0031932cellular_componentTORC2 complex
c0032008biological_processpositive regulation of TOR signaling
c0032956biological_processregulation of actin cytoskeleton organization
c0038202biological_processTORC1 signaling
c0038203biological_processTORC2 signaling
c0043066biological_processnegative regulation of apoptotic process
c0043539molecular_functionprotein serine/threonine kinase activator activity
c0045821biological_processpositive regulation of glycolytic process
c0046889biological_processpositive regulation of lipid biosynthetic process
c0071456biological_processcellular response to hypoxia
c0071470biological_processcellular response to osmotic stress
c1905857biological_processpositive regulation of pentose-phosphate shunt
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006974biological_processDNA damage response
C0007010biological_processcytoskeleton organization
C0010507biological_processnegative regulation of autophagy
C0030307biological_processpositive regulation of cell growth
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031669biological_processcellular response to nutrient levels
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0032008biological_processpositive regulation of TOR signaling
C0032956biological_processregulation of actin cytoskeleton organization
C0038202biological_processTORC1 signaling
C0038203biological_processTORC2 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045821biological_processpositive regulation of glycolytic process
C0046889biological_processpositive regulation of lipid biosynthetic process
C0071456biological_processcellular response to hypoxia
C0071470biological_processcellular response to osmotic stress
C1905857biological_processpositive regulation of pentose-phosphate shunt
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
CMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues108
DetailsRepeat: {"description":"HEAT 6"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues72
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues100
DetailsRepeat: {"description":"HEAT 8"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues88
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues66
DetailsRepeat: {"description":"HEAT 13"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues64
DetailsRepeat: {"description":"HEAT 14"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues78
DetailsRepeat: {"description":"HEAT 15"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues92
DetailsRepeat: {"description":"HEAT 16"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues76
DetailsRepeat: {"description":"HEAT 17"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues78
DetailsRepeat: {"description":"HEAT 18"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues84
DetailsRepeat: {"description":"HEAT 19"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues78
DetailsRepeat: {"description":"HEAT 20"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues72
DetailsRepeat: {"description":"HEAT 21"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues90
DetailsRepeat: {"description":"HEAT 23"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues76
DetailsRepeat: {"description":"HEAT 24"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues78
DetailsRepeat: {"description":"HEAT 25"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues72
DetailsRepeat: {"description":"HEAT 26"}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues76
DetailsRepeat: {"description":"HEAT 27"}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues86
DetailsRepeat: {"description":"HEAT 28"}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues74
DetailsRepeat: {"description":"HEAT 31"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues66
DetailsRepeat: {"description":"HEAT 32"}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues72
DetailsRepeat: {"description":"TPR 1"}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues50
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues66
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues60
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues66
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues66
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues64
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues78
DetailsRepeat: {"description":"TPR 8"}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues68
DetailsRepeat: {"description":"TPR 9"}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues86
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues74
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues108
DetailsRepeat: {"description":"TPR 12"}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues64
DetailsRepeat: {"description":"TPR 14"}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues78
DetailsRepeat: {"description":"TPR 15"}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues68
DetailsRepeat: {"description":"TPR 16"}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues64
DetailsDomain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues264
DetailsRegion: {"description":"Sufficient for interaction with the FKBP1A/rapamycin complex","evidences":[{"source":"UniProtKB","id":"Q9JLN9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues76
DetailsRegion: {"description":"Interaction with MLST8"}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues16
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues50
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33158864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ZWM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19487463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by TBK1","evidences":[{"source":"PubMed","id":"21576368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29150432","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21576368","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"24247430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37979583","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues78
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"31530866","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by MAPK8","evidences":[{"source":"PubMed","id":"19864431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22493283","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31530866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by MAPK8","evidences":[{"source":"PubMed","id":"19864431","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22493283","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31530866","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by RPS6KA1","evidences":[{"source":"PubMed","id":"18722121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by RPS6KA1","evidences":[{"source":"PubMed","id":"18722121","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK and RPS6KA1","evidences":[{"source":"PubMed","id":"18439900","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18722121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"31112131","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI63
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"18439900","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI64
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30197302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32561715","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI65
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI66
Number of Residues80
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI67
Number of Residues78
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI68
Number of Residues78
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI69
Number of Residues78
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI70
Number of Residues78
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI71
Number of Residues82
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI72
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"34741373","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI73
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)","evidences":[{"source":"PubMed","id":"38395307","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI74
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28489822","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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