5H3S
apo form of GEMIN5-WD
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide GOL B 801 and HIS B 717 |
| Chain | Residue |
| A | ARG679 |
| A | ASP716 |
| A | HIS717 |
| B | ASN677 |
| B | ARG679 |
| B | GLN715 |
| B | ASP716 |
| B | SER718 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. CATSsdDgTVKIWDV |
| Chain | Residue | Details |
| A | CYS82-VAL96 | |
| A | LEU395-THR409 | |
| A | LEU655-ALA669 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"WD 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 7 |
| Details | Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG.","authors":["Chao X.","Tempel W.","Bian C.","He H.","Cerovina T.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Min J."]}},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with U4 snRNA and with the 7-methylguanosine cap of RNA molecules","evidences":[{"source":"PubMed","id":"27834343","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27881601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H1K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
