Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue UMP A 401 |
| Chain | Residue |
| A | ARG74 |
| A | ASN250 |
| A | HIS280 |
| A | TYR282 |
| A | HOH530 |
| A | HOH550 |
| A | HOH552 |
| B | ARG199 |
| B | ARG200 |
| A | CYS219 |
| A | HIS220 |
| A | GLN238 |
| A | ARG239 |
| A | SER240 |
| A | GLY241 |
| A | ASP242 |
| A | GLY246 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue UMP B 401 |
| Chain | Residue |
| A | ARG199 |
| A | ARG200 |
| B | CYS219 |
| B | HIS220 |
| B | GLN238 |
| B | ARG239 |
| B | SER240 |
| B | GLY241 |
| B | ASP242 |
| B | GLY246 |
| B | ASN250 |
| B | HIS280 |
| B | TYR282 |
| B | HOH516 |
| B | HOH573 |
| B | HOH583 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNpadlslma.....LpPCHllcQFyV |
| Chain | Residue | Details |
| A | ARG199-VAL227 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS219 | |
| B | CYS219 | |
| Chain | Residue | Details |
| A | ARG74 | |
| A | ARG239 | |
| A | ASN250 | |
| A | HIS280 | |
| B | ARG74 | |
| B | ARG239 | |
| B | ASN250 | |
| B | HIS280 | |
| Chain | Residue | Details |
| A | ARG199 | |
| A | ASP242 | |
| B | ARG199 | |
| B | ASP242 | |
