5H21

Trimethoxy-ring inhibitor in complex with the first bromodomain of BRD4

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue RMR A 201

Chain	Residue
A	TRP81
A	HOH326
A	HOH354
A	HOH404
A	PRO82
A	LEU92
A	ASP96
A	TYR97
A	LYS99
A	TYR139
A	ASN140
A	ILE146

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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