5GZP

Y74COX MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0042802	molecular_function	identical protein binding
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0042802	molecular_function	identical protein binding
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue PGA A 301

Chain	Residue
A	ASN10
A	LEU230
A	GLY232
A	ASN233
A	HOH415
A	HOH433
A	HOH456
A	HOH480
A	LYS12
A	HIS95
A	GLU165
A	ALA169
A	ILE170
A	GLY171
A	GLY210
A	SER211

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	ARG52
A	SER57
A	HOH409

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 303

Chain	Residue
A	THR177
A	HOH408
A	HOH525

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 304

Chain	Residue
A	SER45
A	GLY76
B	SER45
B	GLY76
B	HOH530

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 305

Chain	Residue
A	TYR5
A	ILE221
A	GLN222
A	HOH413
A	HOH487

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 306

Chain	Residue
A	GLU81
A	LYS84
A	ASP85
A	HOH417
A	HOH499

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 307

Chain	Residue
A	LYS237
A	GLU238
A	SER239
A	HOH511

---

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 308

Chain	Residue
A	TRP11
A	ASN14
A	GLY15
A	SER19
A	ILE20
A	LEU23
A	LEU236
A	HOH457

---

site_id	AC9
Number of Residues	16
Details	binding site for residue PGA B 301

Chain	Residue
B	ASN10
B	LYS12
B	HIS95
B	GLU165
B	ALA169
B	ILE170
B	GLY171
B	GLY210
B	SER211
B	LEU230
B	GLY232
B	ASN233
B	HOH435
B	HOH439
B	HOH456
B	HOH492

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO B 302

Chain	Residue
B	LYS237
B	GLU238
B	SER239
B	HOH445

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO B 303

Chain	Residue
B	THR177
B	GLU179
B	GLN180
B	HOH402

---

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO B 304

Chain	Residue
B	ARG52
B	SER57
B	SER60

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO B 305

Chain	Residue
B	THR172
B	LYS174

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG

Chain	Residue	Details
A	VAL163-GLY173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Electrophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---