5GXJ
Zika Virus NS2B-NS3 protease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0044423 | cellular_component | virion component |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0044423 | cellular_component | virion component |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860 |
| Chain | Residue | Details |
| A | HIS1051 | |
| B | GLU1104 | |
| A | ASP1075 | |
| A | SER1135 | |
| B | HIS1051 | |
| B | ASP1075 | |
| B | SER1135 | |
| A | CYS1080 | |
| A | GLU1104 | |
| B | CYS1080 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | INTRAMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY101-ASP1020 | |
| B | GLY101-ASP1020 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860, ECO:0000269|PubMed:29526431 |
| Chain | Residue | Details |
| A | ALA1164 | |
| B | ALA1164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935 |
| Chain | Residue | Details |
| A | ARG1029 | |
| B | ARG1029 |
