5GWF

FraC with GlcNAc(6S) bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0008289	molecular_function	lipid binding
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0031640	biological_process	killing of cells of another organism
A	0035821	biological_process	modulation of process of another organism
A	0042151	cellular_component	nematocyst
A	0042802	molecular_function	identical protein binding
A	0044218	cellular_component	other organism cell membrane
A	0046930	cellular_component	pore complex
A	0046931	biological_process	pore complex assembly
A	0051715	biological_process	cytolysis in another organism
A	0055085	biological_process	transmembrane transport
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0008289	molecular_function	lipid binding
B	0015267	molecular_function	channel activity
B	0016020	cellular_component	membrane
B	0031640	biological_process	killing of cells of another organism
B	0035821	biological_process	modulation of process of another organism
B	0042151	cellular_component	nematocyst
B	0042802	molecular_function	identical protein binding
B	0044218	cellular_component	other organism cell membrane
B	0046930	cellular_component	pore complex
B	0046931	biological_process	pore complex assembly
B	0051715	biological_process	cytolysis in another organism
B	0055085	biological_process	transmembrane transport
B	0090729	molecular_function	toxin activity
C	0005576	cellular_component	extracellular region
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0008289	molecular_function	lipid binding
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0031640	biological_process	killing of cells of another organism
C	0035821	biological_process	modulation of process of another organism
C	0042151	cellular_component	nematocyst
C	0042802	molecular_function	identical protein binding
C	0044218	cellular_component	other organism cell membrane
C	0046930	cellular_component	pore complex
C	0046931	biological_process	pore complex assembly
C	0051715	biological_process	cytolysis in another organism
C	0055085	biological_process	transmembrane transport
C	0090729	molecular_function	toxin activity
D	0005576	cellular_component	extracellular region
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0008289	molecular_function	lipid binding
D	0015267	molecular_function	channel activity
D	0016020	cellular_component	membrane
D	0031640	biological_process	killing of cells of another organism
D	0035821	biological_process	modulation of process of another organism
D	0042151	cellular_component	nematocyst
D	0042802	molecular_function	identical protein binding
D	0044218	cellular_component	other organism cell membrane
D	0046930	cellular_component	pore complex
D	0046931	biological_process	pore complex assembly
D	0051715	biological_process	cytolysis in another organism
D	0055085	biological_process	transmembrane transport
D	0090729	molecular_function	toxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: in subunit A; in oligomeric forms only => ECO:0000305|PubMed:25716479

Chain	Residue	Details
A	ARG31
A	GLY168
B	ARG31
B	GLY168
C	ARG31
C	GLY168
D	ARG31
D	GLY168

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:28630155

Chain	Residue	Details
A	TYR51
D	TYR51
D	ARG53
D	TYR138
A	ARG53
A	TYR138
B	TYR51
B	ARG53
B	TYR138
C	TYR51
C	ARG53
C	TYR138

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING: in monomeric and oligomeric forms => ECO:0000305|PubMed:25716479

Chain	Residue	Details
A	SER54
B	SER54
B	GLY85
B	TYR108
B	TYR113
B	SER114
B	TRP116
B	TYR133
B	TYR137
B	ARG144
C	SER54
A	GLY85
C	GLY85
C	TYR108
C	TYR113
C	SER114
C	TRP116
C	TYR133
C	TYR137
C	ARG144
D	SER54
D	GLY85
A	TYR108
D	TYR108
D	TYR113
D	SER114
D	TRP116
D	TYR133
D	TYR137
D	ARG144
A	TYR113
A	SER114
A	TRP116
A	TYR133
A	TYR137
A	ARG144

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: in subunit B; in oligomeric forms only => ECO:0000305|PubMed:25716479

Chain	Residue	Details
A	ARG79
B	ARG79
C	ARG79
D	ARG79

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Part of the hydrophobic cavity (in subunit A) that receives Val-60 from the adjacent subunit (B); essential in hemolysis, since it is critical for pore formation in cholesterol-rich membrane cells (such as red blood cells) => ECO:0000305|PubMed:21300287, ECO:0000305|PubMed:25716479, ECO:0000305|PubMed:25759390

Chain	Residue	Details
A	PHE16
B	PHE16
C	PHE16
D	PHE16

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: Protrudes from one subunit (B) and inserts into the hydrophobic cavity from the adjacent subunit (A) => ECO:0000305|PubMed:21300287, ECO:0000305|PubMed:25716479

Chain	Residue	Details
A	VAL60
B	VAL60
C	VAL60
D	VAL60

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	SITE: Part of the hydrophobic cavity (in subunit A) that receives Val-60 from the adjacent subunit (B) => ECO:0000305|PubMed:21300287, ECO:0000305|PubMed:25716479

Chain	Residue	Details
A	TRP149
B	TRP149
C	TRP149
D	TRP149

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	SITE: Part of the hydrophobic cavity (in subunit A) that receives Val-60 from the adjacent subunit (B) => ECO:0000305|PubMed:21300287

Chain	Residue	Details
A	PHE163
B	PHE163
C	PHE163
D	PHE163

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