5GWE
cytochrome P450 CREJ
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | PHE98 |
| A | THR296 |
| A | THR297 |
| A | TRP342 |
| A | ARG344 |
| A | MET367 |
| A | SER395 |
| A | PHE396 |
| A | PHE398 |
| A | HIS401 |
| A | CYS403 |
| A | LEU135 |
| A | GLY405 |
| A | ALA409 |
| A | GWM502 |
| A | HOH639 |
| A | HOH671 |
| A | HOH679 |
| A | SER136 |
| A | HIS143 |
| A | ARG147 |
| A | PHE154 |
| A | SER288 |
| A | ALA292 |
| A | GLY293 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue GWM A 502 |
| Chain | Residue |
| A | GLN110 |
| A | SER133 |
| A | GLY134 |
| A | LEU135 |
| A | SER136 |
| A | ARG221 |
| A | SER288 |
| A | PHE291 |
| A | ALA292 |
| A | ILE339 |
| A | TRP342 |
| A | HEM501 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | PHE65 |
| A | ARG306 |
| A | TYR335 |
| A | ARG372 |
| A | ARG444 |
| A | HOH625 |
| A | HOH673 |
| A | HOH843 |
| A | HOH866 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | ARG147 |
| A | GLN151 |
| A | HOH609 |
| A | HOH802 |
| A | HOH877 |
| A | HOH959 |
| A | HOH962 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | PHE98 |
| B | LEU135 |
| B | SER136 |
| B | HIS143 |
| B | ARG147 |
| B | ILE200 |
| B | SER288 |
| B | ALA292 |
| B | GLY293 |
| B | THR296 |
| B | THR297 |
| B | LEU300 |
| B | TRP342 |
| B | ARG344 |
| B | MET367 |
| B | SER395 |
| B | PHE396 |
| B | GLY397 |
| B | PHE398 |
| B | HIS401 |
| B | CYS403 |
| B | LEU404 |
| B | GLY405 |
| B | ALA409 |
| B | GWM502 |
| B | HOH648 |
| B | HOH668 |
| B | HOH715 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue GWM B 502 |
| Chain | Residue |
| B | GLN110 |
| B | SER133 |
| B | GLY134 |
| B | LEU135 |
| B | SER136 |
| B | ARG221 |
| B | SER288 |
| B | PHE291 |
| B | ALA292 |
| B | ILE339 |
| B | TRP342 |
| B | HEM501 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | HOH693 |
| B | HOH714 |
| B | ASN63 |
| B | PHE65 |
| B | ARG306 |
| B | TYR335 |
| B | ARG372 |
| B | ARG444 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | ARG114 |
| B | HOH609 |
| B | HOH682 |
| D | ARG147 |
| D | GLN151 |
| D | HOH678 |
| site_id | AC9 |
| Number of Residues | 28 |
| Details | binding site for residue HEM C 501 |
| Chain | Residue |
| C | PHE98 |
| C | LEU135 |
| C | SER136 |
| C | HIS143 |
| C | ARG147 |
| C | PHE154 |
| C | ILE200 |
| C | SER288 |
| C | ALA292 |
| C | GLY293 |
| C | THR296 |
| C | THR297 |
| C | LEU300 |
| C | TRP342 |
| C | ARG344 |
| C | MET367 |
| C | SER395 |
| C | PHE396 |
| C | GLY397 |
| C | PHE398 |
| C | HIS401 |
| C | CYS403 |
| C | GLY405 |
| C | ALA409 |
| C | GWM502 |
| C | HOH657 |
| C | HOH725 |
| C | HOH751 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue GWM C 502 |
| Chain | Residue |
| C | GLN110 |
| C | SER133 |
| C | GLY134 |
| C | LEU135 |
| C | SER136 |
| C | ARG221 |
| C | SER288 |
| C | PHE291 |
| C | ALA292 |
| C | ILE339 |
| C | TRP342 |
| C | HEM501 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 C 503 |
| Chain | Residue |
| C | PHE65 |
| C | ARG306 |
| C | TYR335 |
| C | ARG372 |
| C | ARG444 |
| C | HOH619 |
| C | HOH764 |
| C | HOH766 |
| C | HOH769 |
| C | HOH786 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 504 |
| Chain | Residue |
| C | ARG147 |
| C | GLN151 |
| C | HOH781 |
| C | HOH837 |
| C | HOH908 |
| C | HOH913 |
| site_id | AD4 |
| Number of Residues | 25 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | PHE98 |
| D | LEU135 |
| D | SER136 |
| D | HIS143 |
| D | ARG147 |
| D | PHE154 |
| D | ILE200 |
| D | SER288 |
| D | ALA292 |
| D | GLY293 |
| D | THR296 |
| D | LEU300 |
| D | ARG344 |
| D | SER395 |
| D | PHE396 |
| D | PHE398 |
| D | HIS401 |
| D | CYS403 |
| D | LEU404 |
| D | GLY405 |
| D | ALA409 |
| D | GWM502 |
| D | HOH629 |
| D | HOH721 |
| D | HOH731 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue GWM D 502 |
| Chain | Residue |
| D | GLN110 |
| D | SER133 |
| D | GLY134 |
| D | LEU135 |
| D | SER136 |
| D | ARG221 |
| D | SER288 |
| D | PHE291 |
| D | ALA292 |
| D | ILE339 |
| D | TRP342 |
| D | HEM501 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 D 503 |
| Chain | Residue |
| D | PHE65 |
| D | ARG306 |
| D | TYR335 |
| D | ARG372 |
| D | ARG444 |
| D | HOH636 |
| D | HOH749 |
| D | HOH754 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGIHYCLG |
| Chain | Residue | Details |
| A | PHE396-GLY405 |
