5GV4
Y74COX MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue PGA A 301 |
| Chain | Residue |
| A | ASN10 |
| A | LEU230 |
| A | GLY232 |
| A | ASN233 |
| A | HOH422 |
| A | HOH427 |
| A | HOH437 |
| A | HOH481 |
| A | LYS12 |
| A | HIS95 |
| A | GLU165 |
| A | ALA169 |
| A | ILE170 |
| A | GLY171 |
| A | GLY210 |
| A | SER211 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | LEU131 |
| A | TRP168 |
| A | GLN180 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ARG52 |
| A | LYS174 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | THR177 |
| A | THR177 |
| A | GLU179 |
| A | GLN180 |
| A | HOH409 |
| A | HOH421 |
| A | HOH421 |
| A | HOH535 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | SER57 |
| A | LYS58 |
| A | SER60 |
| A | GLU89 |
| A | HOH510 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | TRP11 |
| A | ASN14 |
| A | GLY15 |
| A | SER19 |
| A | ILE20 |
| A | LEU236 |
| A | HOH443 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG |
| Chain | Residue | Details |
| A | VAL163-GLY173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Electrophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
