Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009060 | biological_process | aerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016966 | molecular_function | nitric oxide reductase activity |
| B | 0019333 | biological_process | denitrification pathway |
| B | 0020037 | molecular_function | heme binding |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue HEM B 801 |
| Chain | Residue |
| B | GLN30 |
| B | HIS349 |
| B | PHE352 |
| B | TYR353 |
| B | HEM802 |
| B | XE809 |
| B | CA814 |
| C | ALA72 |
| C | TYR73 |
| C | PHE74 |
| B | ILE31 |
| B | GLY34 |
| B | MET37 |
| B | TYR41 |
| B | ARG57 |
| B | HIS60 |
| B | LEU64 |
| B | GLU135 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue HEM B 802 |
| Chain | Residue |
| B | GLU135 |
| B | PHE136 |
| B | TRP203 |
| B | VAL210 |
| B | GLU211 |
| B | HIS258 |
| B | HIS259 |
| B | SER277 |
| B | GLU280 |
| B | ALA322 |
| B | GLY326 |
| B | PHE327 |
| B | HIS329 |
| B | THR330 |
| B | ASN335 |
| B | HIS339 |
| B | GLY340 |
| B | THR344 |
| B | HIS347 |
| B | ALA351 |
| B | PHE352 |
| B | ALA355 |
| B | HEM801 |
| B | O804 |
| B | CA814 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FE B 803 |
| Chain | Residue |
| B | HIS207 |
| B | GLU211 |
| B | HIS258 |
| B | HIS259 |
| B | O804 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue O B 804 |
| Chain | Residue |
| B | GLU211 |
| B | HIS258 |
| B | HIS259 |
| B | HEM802 |
| B | FE803 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue XE B 807 |
| Chain | Residue |
| B | LEU181 |
| B | PHE185 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue XE B 808 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue XE B 809 |
| Chain | Residue |
| B | PHE136 |
| B | HEM801 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue 10M B 812 |
| Chain | Residue |
| B | LEU270 |
| B | TRP271 |
| B | TYR336 |
| B | TYR337 |
| B | 10M813 |
| C | ASN138 |
| C | GLN139 |
| C | PRO142 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 10M B 813 |
| Chain | Residue |
| B | TYR337 |
| B | MET417 |
| B | ALA419 |
| B | 10M812 |
| L | THR202 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 814 |
| Chain | Residue |
| B | ARG57 |
| B | GLU135 |
| B | HEM801 |
| B | HEM802 |
| C | GLY71 |
| C | TYR73 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue HEC C 201 |
| Chain | Residue |
| B | ASN54 |
| B | MET427 |
| C | CYS61 |
| C | CYS64 |
| C | HIS65 |
| C | ALA75 |
| C | PRO76 |
| C | LEU78 |
| C | VAL81 |
| C | ARG84 |
| C | ARG85 |
| C | TRP98 |
| C | ARG109 |
| C | ARG110 |
| C | ALA111 |
| C | MET112 |
| C | PRO113 |
| C | PHE115 |
| C | LEU125 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 57 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WWVVHLwVegvwelimgailafvlvkitgvdreviekwlyviiamalisgiigtgHH |
| Chain | Residue | Details |
| B | TRP203-HIS259 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]} |
