5GUW

Complex of Cytochrome cd1 Nitrite Reductase and Nitric Oxide Reductase in Denitrification of Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0046872	molecular_function	metal ion binding
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005886	cellular_component	plasma membrane
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016966	molecular_function	nitric oxide reductase activity
B	0019333	biological_process	denitrification pathway
B	0020037	molecular_function	heme binding
B	0022904	biological_process	respiratory electron transport chain
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0046872	molecular_function	metal ion binding
D	0004129	molecular_function	cytochrome-c oxidase activity
D	0005886	cellular_component	plasma membrane
D	0009060	biological_process	aerobic respiration
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016966	molecular_function	nitric oxide reductase activity
D	0019333	biological_process	denitrification pathway
D	0020037	molecular_function	heme binding
D	0022904	biological_process	respiratory electron transport chain
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport
M	0009055	molecular_function	electron transfer activity
M	0020037	molecular_function	heme binding
N	0009055	molecular_function	electron transfer activity
N	0020037	molecular_function	heme binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue HEC A 201

Chain	Residue
A	ASN59
A	LEU95
A	TRP98
A	ARG109
A	ARG110
A	ALA111
A	MET112
A	PRO113
A	PHE115
A	LEU125
B	MET427
A	CYS61
A	CYS64
A	HIS65
A	ALA75
A	LEU78
A	VAL81
A	ARG84
A	ARG85

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 202

Chain	Residue
A	GLY71
A	TYR73
B	ARG57
B	GLU135
B	HEM801
B	HEM802

---

site_id	AC3
Number of Residues	7
Details	binding site for residue 10M A 203

Chain	Residue
A	ASN138
A	GLN139
A	PRO142
B	LEU270
B	TRP271
B	TYR336
B	TYR337

---

site_id	AC4
Number of Residues	22
Details	binding site for residue HEM B 801

Chain	Residue
A	ALA72
A	TYR73
A	PHE74
A	CA202
B	GLN30
B	ILE31
B	GLY34
B	LEU35
B	MET37
B	TYR41
B	PHE53
B	ARG57
B	HIS60
B	LEU64
B	GLU135
B	HIS349
B	PHE352
B	TYR353
B	MET397
B	GLU441
B	PHE447
B	HEM802

---

site_id	AC5
Number of Residues	24
Details	binding site for residue HEM B 802

Chain	Residue
A	TYR73
A	CA202
B	GLU135
B	VAL210
B	GLU211
B	HIS258
B	HIS259
B	SER277
B	GLU280
B	ALA322
B	GLY326
B	PHE327
B	HIS329
B	THR330
B	ASN335
B	HIS339
B	THR344
B	HIS347
B	ALA351
B	PHE352
B	ALA355
B	TYR356
B	HEM801
B	O804

---

site_id	AC6
Number of Residues	5
Details	binding site for residue FE B 803

Chain	Residue
B	HIS207
B	GLU211
B	HIS258
B	HIS259
B	O804

---

site_id	AC7
Number of Residues	4
Details	binding site for residue O B 804

Chain	Residue
B	GLU211
B	HIS259
B	HEM802
B	FE803

---

site_id	AC8
Number of Residues	19
Details	binding site for residue HEC C 201

Chain	Residue
C	ALA111
C	MET112
C	PHE115
C	LEU125
D	PHE53
D	ASN54
D	MET427
C	CYS61
C	CYS64
C	HIS65
C	ALA75
C	LEU78
C	VAL81
C	ARG84
C	ARG85
C	LEU95
C	TRP98
C	ARG109
C	ARG110

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA C 202

Chain	Residue
C	GLY71
C	TYR73
D	GLU135
D	HEM801
D	HEM802

---

site_id	AD1
Number of Residues	9
Details	binding site for residue 10M C 203

Chain	Residue
C	ASN138
C	GLN139
C	PRO142
C	HOH301
D	LEU270
D	TRP271
D	TYR336
D	TYR337
D	10M805

---

site_id	AD2
Number of Residues	21
Details	binding site for residue HEM D 801

Chain	Residue
C	ALA72
C	TYR73
C	PHE74
C	CA202
D	GLN30
D	ILE31
D	GLY34
D	LEU35
D	MET37
D	TYR41
D	PHE53
D	ARG57
D	HIS60
D	LEU64
D	GLU135
D	HIS349
D	PHE352
D	TYR353
D	MET397
D	PHE447
D	HEM802

---

site_id	AD3
Number of Residues	26
Details	binding site for residue HEM D 802

Chain	Residue
C	CA202
D	GLU135
D	PHE136
D	TRP203
D	VAL210
D	GLU211
D	HIS258
D	HIS259
D	GLU280
D	PHE284
D	ALA322
D	GLY326
D	PHE327
D	HIS329
D	THR330
D	ASN335
D	HIS339
D	GLY340
D	THR344
D	HIS347
D	ALA351
D	PHE352
D	ALA355
D	TYR356
D	HEM801
D	O804

---

site_id	AD4
Number of Residues	5
Details	binding site for residue FE D 803

Chain	Residue
D	HIS207
D	GLU211
D	HIS258
D	HIS259
D	O804

---

site_id	AD5
Number of Residues	4
Details	binding site for residue O D 804

Chain	Residue
D	GLU211
D	HIS259
D	HEM802
D	FE803

---

site_id	AD6
Number of Residues	4
Details	binding site for residue 10M D 805

Chain	Residue
C	10M203
D	MET328
D	MET417
D	ALA419

---

site_id	AD7
Number of Residues	20
Details	binding site for residue DHE M 602

Chain	Residue
M	ARG156
M	HIS182
M	ILE183
M	ARG185
M	ARG198
M	ARG225
M	SER226
M	TYR245
M	ALA283
M	ALA284
M	ILE285
M	HIS327
M	ARG372
M	PHE425
M	GLN483
M	TRP498
M	GLY531
M	PHE533
N	TYR10
N	ALA13

---

site_id	AD8
Number of Residues	3
Details	binding site for residue CL M 603

Chain	Residue
M	GLY268
M	MET269
N	SER265

---

site_id	AD9
Number of Residues	19
Details	binding site for residue DHE N 602

Chain	Residue
M	TYR10
M	ALA13
N	ARG156
N	HIS182
N	ILE183
N	ARG185
N	ARG198
N	ARG225
N	SER226
N	TYR245
N	ALA283
N	ALA284
N	ILE285
N	HIS327
N	ARG372
N	PHE425
N	GLN483
N	GLY531
N	PHE533

---

site_id	AE1
Number of Residues	3
Details	binding site for residue CL N 603

Chain	Residue
M	SER265
N	GLY268
N	MET269

---

site_id	AE2
Number of Residues	21
Details	binding site for Di-peptide HEC M 601 and CYS M 50

Chain	Residue
M	ARG46
M	CYS47
M	ALA48
M	GLY49
M	HIS51
M	GLY52
M	GLY57
M	ALA58
M	THR59
M	LYS61
M	LEU63
M	ARG71
M	TYR75
M	LEU79
M	THR84
M	LEU86
M	GLY87
M	MET88
M	PRO89
M	TRP91
M	ILE109

---

site_id	AE3
Number of Residues	19
Details	binding site for Di-peptide HEC M 601 and CYS M 47

Chain	Residue
M	TYR43
M	ARG46
M	ALA48
M	GLY49
M	CYS50
M	HIS51
M	THR59
M	LYS61
M	LEU63
M	ARG71
M	TYR75
M	LEU79
M	THR84
M	LEU86
M	GLY87
M	MET88
M	PRO89
M	TRP91
M	ILE109

---

site_id	AE4
Number of Residues	20
Details	binding site for Di-peptide HEC N 601 and CYS N 50

Chain	Residue
M	GLU8
N	ARG46
N	CYS47
N	ALA48
N	GLY49
N	HIS51
N	GLY52
N	GLY57
N	ALA58
N	THR59
N	LEU63
N	ARG71
N	TYR75
N	LEU79
N	THR84
N	LEU86
N	GLY87
N	MET88
N	TRP91
N	ILE109

---

site_id	AE5
Number of Residues	18
Details	binding site for Di-peptide HEC N 601 and CYS N 47

Chain	Residue
M	GLU8
N	TYR43
N	ARG46
N	ALA48
N	GLY49
N	CYS50
N	HIS51
N	THR59
N	LEU63
N	ARG71
N	TYR75
N	LEU79
N	THR84
N	LEU86
N	GLY87
N	MET88
N	TRP91
N	ILE109

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	57
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WWVVHLwVegvwelimgailafvlvkitgvdreviekwlyviiamalisgiigtgHH

Chain	Residue	Details
B	TRP203-HIS259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Signal-anchor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"axial binding residue","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	170
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	854
Details	Region: {"description":"D1-heme domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"9331415","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9331415","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9331415","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"9331415","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 903

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 903

Chain

Residue

Details

---