5GUH

Crystal structure of silkworm PIWI-clade Argonaute Siwi bound to piRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0007283	biological_process	spermatogenesis
A	0016787	molecular_function	hydrolase activity
A	0030154	biological_process	cell differentiation
A	0030237	biological_process	female sex determination
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0034584	molecular_function	piRNA binding
A	0034587	biological_process	piRNA processing
A	0046872	molecular_function	metal ion binding
A	0051321	biological_process	meiotic cell cycle
A	0140965	biological_process	secondary piRNA processing
A	0140991	biological_process	piRNA-mediated gene silencing by mRNA destabilization
A	1990923	cellular_component	PET complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 901

Chain	Residue
A	GLN645
A	LEU899
A	HOH1027
B	U1
B	U3

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site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 902

Chain	Residue
A	ASP740
A	LYS780

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:27693359, ECO:0007744|PDB:5GUH

Chain	Residue	Details
A	ASP670
A	GLU708
A	ASP740
A	HIS874

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:27693359, ECO:0007744|PDB:5GUH

Chain	Residue	Details
A	GLN645
A	LEU899

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