5GUG
Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain with inositol 1,4,5-trisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue I3P A 3000 |
| Chain | Residue |
| A | ARG265 |
| A | THR267 |
| A | GLY268 |
| A | ARG269 |
| A | ALA275 |
| A | LYS508 |
| A | TYR567 |
| A | ARG568 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue I3P B 3000 |
| Chain | Residue |
| B | GLY268 |
| B | ARG269 |
| B | ARG504 |
| B | LYS508 |
| B | ARG511 |
| B | TYR567 |
| B | ARG568 |
| B | LYS569 |
| B | THR267 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12442173, ECO:0000269|PubMed:28416699, ECO:0007744|PDB:1N4K, ECO:0007744|PDB:5GUG, ECO:0007744|PDB:5XA1 |
| Chain | Residue | Details |
| A | ARG265 | |
| B | GLY268 | |
| B | ARG269 | |
| B | LYS508 | |
| B | TYR567 | |
| B | ARG568 | |
| A | THR267 | |
| A | GLY268 | |
| A | ARG269 | |
| A | LYS508 | |
| A | TYR567 | |
| A | ARG568 | |
| B | ARG265 | |
| B | THR267 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12442173, ECO:0007744|PDB:1N4K |
| Chain | Residue | Details |
| A | ARG511 | |
| B | ARG511 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q14573 |
| Chain | Residue | Details |
| A | ARG747 | |
| B | GLU2041 | |
| A | GLU1127 | |
| A | GLU1130 | |
| A | GLU1977 | |
| A | GLU2041 | |
| B | ARG747 | |
| B | GLU1127 | |
| B | GLU1130 | |
| B | GLU1977 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17208939, ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER1588 | |
| B | SER1588 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P29994 |
| Chain | Residue | Details |
| A | SER1755 | |
| B | SER1755 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:25368151 |
| Chain | Residue | Details |
| A | CYS56 | |
| A | CYS849 | |
| B | CYS56 | |
| B | CYS849 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P29994 |
| Chain | Residue | Details |
| A | LYS916 | |
| A | LYS1924 | |
| A | LYS2118 | |
| B | LYS916 | |
| B | LYS962 | |
| B | LYS1571 | |
| B | LYS1771 | |
| B | LYS1884 | |
| B | LYS1885 | |
| B | LYS1886 | |
| B | LYS1901 | |
| B | LYS1924 | |
| B | LYS2118 | |
| A | LYS962 | |
| A | LYS1571 | |
| A | LYS1771 | |
| A | LYS1884 | |
| A | LYS1885 | |
| A | LYS1886 | |
| A | LYS1901 |
