5GT7
Crystal Structure of Arg-bound CASTOR1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0034618 | molecular_function | arginine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0061700 | cellular_component | GATOR2 complex |
| A | 0140299 | molecular_function | small molecule sensor activity |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1903577 | biological_process | cellular response to L-arginine |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0034198 | biological_process | cellular response to amino acid starvation |
| B | 0034618 | molecular_function | arginine binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0061700 | cellular_component | GATOR2 complex |
| B | 0140299 | molecular_function | small molecule sensor activity |
| B | 0140311 | molecular_function | protein sequestering activity |
| B | 1903577 | biological_process | cellular response to L-arginine |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
| B | 1904263 | biological_process | positive regulation of TORC1 signaling |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0034198 | biological_process | cellular response to amino acid starvation |
| C | 0034618 | molecular_function | arginine binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0061700 | cellular_component | GATOR2 complex |
| C | 0140299 | molecular_function | small molecule sensor activity |
| C | 0140311 | molecular_function | protein sequestering activity |
| C | 1903577 | biological_process | cellular response to L-arginine |
| C | 1904262 | biological_process | negative regulation of TORC1 signaling |
| C | 1904263 | biological_process | positive regulation of TORC1 signaling |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0034198 | biological_process | cellular response to amino acid starvation |
| D | 0034618 | molecular_function | arginine binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0061700 | cellular_component | GATOR2 complex |
| D | 0140299 | molecular_function | small molecule sensor activity |
| D | 0140311 | molecular_function | protein sequestering activity |
| D | 1903577 | biological_process | cellular response to L-arginine |
| D | 1904262 | biological_process | negative regulation of TORC1 signaling |
| D | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ARG A 401 |
| Chain | Residue |
| A | SER111 |
| A | SER299 |
| A | THR300 |
| A | PHE301 |
| A | PHE303 |
| A | ASP304 |
| A | HOH527 |
| A | HOH555 |
| A | HOH557 |
| A | VAL112 |
| A | LEU273 |
| A | GLY274 |
| A | GLU277 |
| A | CYS278 |
| A | GLY279 |
| A | ILE280 |
| A | VAL281 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MLI A 402 |
| Chain | Residue |
| A | THR199 |
| A | THR200 |
| A | ASP203 |
| A | HOH574 |
| B | LEU33 |
| B | PRO195 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MLI A 403 |
| Chain | Residue |
| A | PHE32 |
| A | PRO195 |
| A | HOH506 |
| B | THR199 |
| B | THR200 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MLI A 404 |
| Chain | Residue |
| A | GLU73 |
| A | ALA74 |
| A | THR75 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue ARG B 401 |
| Chain | Residue |
| B | SER111 |
| B | VAL112 |
| B | LEU273 |
| B | GLY274 |
| B | GLU277 |
| B | GLY279 |
| B | ILE280 |
| B | VAL281 |
| B | SER299 |
| B | THR300 |
| B | PHE301 |
| B | PHE303 |
| B | ASP304 |
| B | HOH517 |
| B | HOH538 |
| B | HOH550 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue ARG C 401 |
| Chain | Residue |
| C | SER111 |
| C | VAL112 |
| C | LEU273 |
| C | GLY274 |
| C | GLU277 |
| C | CYS278 |
| C | GLY279 |
| C | ILE280 |
| C | VAL281 |
| C | SER299 |
| C | THR300 |
| C | PHE301 |
| C | PHE303 |
| C | ASP304 |
| C | HOH549 |
| C | HOH556 |
| C | HOH581 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue MLI C 402 |
| Chain | Residue |
| C | THR199 |
| C | THR200 |
| C | ASP203 |
| C | HOH582 |
| C | HOH609 |
| D | PHE32 |
| D | PRO195 |
| D | HOH527 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue ARG D 401 |
| Chain | Residue |
| D | SER111 |
| D | VAL112 |
| D | LEU113 |
| D | LEU273 |
| D | GLY274 |
| D | GLU277 |
| D | CYS278 |
| D | GLY279 |
| D | ILE280 |
| D | VAL281 |
| D | SER299 |
| D | THR300 |
| D | PHE301 |
| D | PHE303 |
| D | ASP304 |
| D | HOH546 |
| D | HOH568 |
| D | HOH585 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue MLI D 402 |
| Chain | Residue |
| D | ARG11 |
| D | ALA74 |
| D | THR75 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MLI D 403 |
| Chain | Residue |
| C | PHE32 |
| D | THR199 |
| D | THR200 |
| D | ASP203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27487210, ECO:0007744|PDB:5I2C |
| Chain | Residue | Details |
| A | SER111 | |
| C | GLY274 | |
| C | ILE280 | |
| C | THR300 | |
| D | SER111 | |
| D | GLY274 | |
| D | ILE280 | |
| D | THR300 | |
| A | GLY274 | |
| A | ILE280 | |
| A | THR300 | |
| B | SER111 | |
| B | GLY274 | |
| B | ILE280 | |
| B | THR300 | |
| C | SER111 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:33594058 |
| Chain | Residue | Details |
| A | SER14 | |
| B | SER14 | |
| C | SER14 | |
| D | SER14 |
