5GSO

Crystal Structures of EV71 3C Protease in complex with NK-1.8k

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0019062	biological_process	virion attachment to host cell
A	0030430	cellular_component	host cell cytoplasm
A	0039618	cellular_component	T=pseudo3 icosahedral viral capsid
A	0046718	biological_process	symbiont entry into host cell
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
B	0019062	biological_process	virion attachment to host cell
B	0030430	cellular_component	host cell cytoplasm
B	0039618	cellular_component	T=pseudo3 icosahedral viral capsid
B	0046718	biological_process	symbiont entry into host cell
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
C	0019062	biological_process	virion attachment to host cell
C	0030430	cellular_component	host cell cytoplasm
C	0039618	cellular_component	T=pseudo3 icosahedral viral capsid
C	0046718	biological_process	symbiont entry into host cell
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
D	0019062	biological_process	virion attachment to host cell
D	0030430	cellular_component	host cell cytoplasm
D	0039618	cellular_component	T=pseudo3 icosahedral viral capsid
D	0046718	biological_process	symbiont entry into host cell
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity
E	0019062	biological_process	virion attachment to host cell
E	0030430	cellular_component	host cell cytoplasm
E	0039618	cellular_component	T=pseudo3 icosahedral viral capsid
E	0046718	biological_process	symbiont entry into host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 5GI A 201

Chain	Residue
A	PHE25
A	HIS161
A	ILE162
A	GLY163
A	GLY164
A	HIS40
A	GLU71
A	LEU127
A	LYS130
A	THR132
A	THR142
A	LYS143
A	CYS147

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site_id	AC2
Number of Residues	20
Details	binding site for Di-peptide 5GI B 201 and CYS B 147

Chain	Residue
B	PHE25
B	THR26
B	ARG39
B	HIS40
B	GLU71
B	LEU127
B	SER128
B	LYS130
B	THR132
B	THR142
B	LYS143
B	ALA144
B	GLY145
B	GLN146
B	GLY148
B	GLY149
B	HIS161
B	ILE162
B	GLY163
B	GLY164

---

site_id	AC3
Number of Residues	17
Details	binding site for Di-peptide 5GI C 201 and CYS C 147

Chain	Residue
C	PHE25
C	THR26
C	HIS40
C	GLU71
C	LEU127
C	SER128
C	LYS130
C	THR142
C	LYS143
C	GLY145
C	GLN146
C	GLY148
C	GLY149
C	HIS161
C	ILE162
C	GLY163
C	GLY164

---

site_id	AC4
Number of Residues	20
Details	binding site for Di-peptide 5GI D 201 and CYS D 147

Chain	Residue
D	PHE25
D	THR26
D	HIS40
D	ASN69
D	GLU71
D	LEU127
D	SER128
D	THR132
D	THR142
D	LYS143
D	ALA144
D	GLY145
D	GLN146
D	GLY148
D	GLY149
D	HIS161
D	ILE162
D	GLY163
D	GLY164
D	HOH304

---

site_id	AC5
Number of Residues	18
Details	binding site for Di-peptide 5GI E 201 and CYS E 147

Chain	Residue
E	PHE25
E	THR26
E	HIS40
E	ASN69
E	GLU71
E	LEU127
E	LYS130
E	THR132
E	THR142
E	LYS143
E	GLY145
E	GLN146
E	GLY148
E	GLY149
E	HIS161
E	ILE162
E	GLY163
E	GLY164

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