5GQQ

Structure of ALG-2/HEBP2 Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA C 201

Chain	Residue
C	ASP36
C	ASP38
C	SER40
C	VAL42
C	GLU47
C	CL204

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA C 202

Chain	Residue
C	MET109
C	GLU114
C	ASP103
C	ASP105
C	SER107

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA C 203

Chain	Residue
C	ASP169
C	ASP171
C	ASP173
C	TRP175
C	HOH360

---

site_id	AC4
Number of Residues	8
Details	binding site for residue CL C 204

Chain	Residue
B	GLN149
B	GLU153
C	ASP38
C	SER40
C	VAL42
C	GLU47
C	CA201
C	HOH344

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA D 201

Chain	Residue
D	ASP36
D	ASP38
D	SER40
D	VAL42
D	GLU47
D	CL204

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA D 202

Chain	Residue
D	ASP103
D	ASP105
D	SER107
D	MET109
D	GLU114

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CA D 203

Chain	Residue
D	ASP169
D	ASP171
D	ASP173
D	TRP175

---

site_id	AC8
Number of Residues	7
Details	binding site for residue CL D 204

Chain	Residue
A	GLU153
D	ASP38
D	SER40
D	VAL42
D	GLU47
D	CA201
D	HOH313

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDRSGVISdtEL

Chain	Residue	Details
C	ASP36-LEU48
C	ASP103-LEU115

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Domain: {"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 4","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	29
Details	Domain: {"description":"EF-hand 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18940611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18997320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20691033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25667979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18940611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18997320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20691033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25667979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P12815","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---