5GQ1
Crystal structure of 2C helicase from enterovirus 71 (EV71)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003724 | molecular_function | RNA helicase activity |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003724 | molecular_function | RNA helicase activity |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003724 | molecular_function | RNA helicase activity |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003724 | molecular_function | RNA helicase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS270 |
| A | CYS281 |
| A | SER282 |
| A | CYS286 |
| A | HOH511 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS270 |
| B | CYS281 |
| B | SER282 |
| B | CYS286 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | GLY132 |
| B | GLY134 |
| B | LYS135 |
| B | SER136 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 401 |
| Chain | Residue |
| C | CYS270 |
| C | CYS281 |
| C | SER282 |
| C | CYS286 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| D | CYS270 |
| D | CYS281 |
| D | SER282 |
| D | CYS286 |
| D | LYS288 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 D 402 |
| Chain | Residue |
| D | GLY134 |
| D | LYS135 |
| D | SER136 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue ZN E 401 |
| Chain | Residue |
| E | CYS281 |
| E | SER282 |
| E | CYS286 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 401 |
| Chain | Residue |
| F | CYS270 |
| F | CYS281 |
| F | SER282 |
| F | CYS286 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | Zinc finger: {"description":"C4-type; degenerate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2017","firstPage":"E1602573","lastPage":"E1602573","volume":"3","journal":"Sci. Adv.","title":"Crystal structure of 2C helicase from enterovirus 71.","authors":["Guan H.X.","Tian J.","Qin B.","Wojdyla J.","Wang B.","Zhao Z.D.","Wang M.T.","Cui S."],"citationCrossReferences":[{"database":"DOI","id":"10.1126/sciadv.1602573"}]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Region: {"description":"RNA-binding","evidences":[{"source":"UniProtKB","id":"P03300","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00551","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2017","firstPage":"E1602573","lastPage":"E1602573","volume":"3","journal":"Sci. Adv.","title":"Crystal structure of 2C helicase from enterovirus 71.","authors":["Guan H.X.","Tian J.","Qin B.","Wojdyla J.","Wang B.","Zhao Z.D.","Wang M.T.","Cui S."],"citationCrossReferences":[{"database":"DOI","id":"10.1126/sciadv.1602573"}]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Region: {"description":"Oligomerization","evidences":[{"source":"UniProtKB","id":"P03300","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
