5GPJ
Crystal Structure of Proton-Pumping Pyrophosphatase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004427 | molecular_function | inorganic diphosphate phosphatase activity |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0009678 | molecular_function | diphosphate hydrolysis-driven proton transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0004427 | molecular_function | inorganic diphosphate phosphatase activity |
| B | 0005774 | cellular_component | vacuolar membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0009678 | molecular_function | diphosphate hydrolysis-driven proton transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0004427 | molecular_function | inorganic diphosphate phosphatase activity |
| C | 0005774 | cellular_component | vacuolar membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0009678 | molecular_function | diphosphate hydrolysis-driven proton transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0004427 | molecular_function | inorganic diphosphate phosphatase activity |
| D | 0005774 | cellular_component | vacuolar membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0009678 | molecular_function | diphosphate hydrolysis-driven proton transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 1001 |
| Chain | Residue |
| A | LYS250 |
| A | ASP253 |
| A | ASP279 |
| A | ASP283 |
| A | ASP507 |
| A | LYS730 |
| A | MG1002 |
| A | MG1003 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | PO41001 |
| A | ASP507 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | ASP253 |
| A | ASP723 |
| A | ASP727 |
| A | LYS730 |
| A | PO41001 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 1001 |
| Chain | Residue |
| B | LYS250 |
| B | ASP253 |
| B | ASP279 |
| B | ASP283 |
| B | ASP507 |
| B | ASP723 |
| B | LYS730 |
| B | MG1002 |
| B | MG1003 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ASP507 |
| B | PO41001 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 1003 |
| Chain | Residue |
| B | ASP253 |
| B | ASP727 |
| B | LYS730 |
| B | PO41001 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 C 1001 |
| Chain | Residue |
| C | LYS250 |
| C | ASP253 |
| C | ASP279 |
| C | ASP283 |
| C | ASP507 |
| C | ASP691 |
| C | LYS730 |
| C | MG1003 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue MG C 1002 |
| Chain | Residue |
| C | ASP507 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 1003 |
| Chain | Residue |
| C | ASP253 |
| C | ASP691 |
| C | ASP723 |
| C | ASP727 |
| C | PO41001 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 1001 |
| Chain | Residue |
| D | LYS250 |
| D | ASP253 |
| D | ASP283 |
| D | ASP507 |
| D | ASN534 |
| D | ASP691 |
| D | ASP727 |
| D | LYS730 |
| D | MG1002 |
| D | MG1003 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 1002 |
| Chain | Residue |
| D | ASP279 |
| D | ASP283 |
| D | ASP507 |
| D | PO41001 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 1003 |
| Chain | Residue |
| D | LYS250 |
| D | ASP253 |
| D | ASP727 |
| D | LYS730 |
| D | PO41001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1700 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 272 |
| Details | Topological domain: {"description":"Intravacuolar","evidences":[{"source":"PubMed","id":"22456709","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 571 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22456709","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22456709","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Site: {"description":"Important for proton transport","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
