Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5GP0

Crystal structure of geraniol-NUDX1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000210	molecular_function	NAD+ diphosphatase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006203	biological_process	dGTP catabolic process
A	0006950	biological_process	response to stress
A	0006974	biological_process	DNA damage response
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0019177	molecular_function	dihydroneopterin triphosphate pyrophosphohydrolase activity
A	0035529	molecular_function	NADH pyrophosphatase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0046872	molecular_function	metal ion binding
E	0000210	molecular_function	NAD+ diphosphatase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006203	biological_process	dGTP catabolic process
E	0006950	biological_process	response to stress
E	0006974	biological_process	DNA damage response
E	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
E	0016787	molecular_function	hydrolase activity
E	0019177	molecular_function	dihydroneopterin triphosphate pyrophosphohydrolase activity
E	0035529	molecular_function	NADH pyrophosphatase activity
E	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
E	0046872	molecular_function	metal ion binding
F	0000210	molecular_function	NAD+ diphosphatase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006203	biological_process	dGTP catabolic process
F	0006950	biological_process	response to stress
F	0006974	biological_process	DNA damage response
F	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
F	0016787	molecular_function	hydrolase activity
F	0019177	molecular_function	dihydroneopterin triphosphate pyrophosphohydrolase activity
F	0035529	molecular_function	NADH pyrophosphatase activity
F	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
F	0046872	molecular_function	metal ion binding
I	0000210	molecular_function	NAD+ diphosphatase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006203	biological_process	dGTP catabolic process
I	0006950	biological_process	response to stress
I	0006974	biological_process	DNA damage response
I	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
I	0016787	molecular_function	hydrolase activity
I	0019177	molecular_function	dihydroneopterin triphosphate pyrophosphohydrolase activity
I	0035529	molecular_function	NADH pyrophosphatase activity
I	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
I	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL E 201

Chain	Residue
E	ARG28
E	SER34
E	HOH312
E	HOH319
E	HOH326
E	HOH348
E	HOH378

site_id	AC2
Number of Residues	15
Details	binding site for residue GPP E 202

Chain	Residue
E	ARG27
E	SER29
E	ALA37
E	LEU38
E	HIS42
E	THR74
E	ASN76
E	PHE78
E	TYR87
E	SER89
E	PHE127
E	PRO129
E	HOH311
E	ALA11
E	VAL13

site_id	AC3
Number of Residues	18
Details	binding site for residue GPP F 201

Chain	Residue
F	ALA11
F	VAL13
F	ARG27
F	SER29
F	ALA37
F	LEU38
F	THR74
F	ASN76
F	PHE78
F	TYR87
F	SER89
F	PHE127
F	PRO129
F	HOH304
F	HOH305
F	HOH315
F	HOH337
F	HOH374

site_id	AC4
Number of Residues	10
Details	binding site for residue GOL I 201

Chain	Residue
A	TYR123
A	PRO129
A	LYS130
I	ARG28
I	GLU112
I	HOH314
I	HOH378
I	HOH389
I	HOH394
I	HOH407

site_id	AC5
Number of Residues	15
Details	binding site for residue GPP I 202

Chain	Residue
I	VAL13
I	ARG27
I	SER29
I	ALA37
I	LEU38
I	HIS42
I	THR74
I	PHE78
I	TYR87
I	SER89
I	PHE127
I	PRO129
I	LEU130
I	HOH304
I	HOH324

site_id	AC6
Number of Residues	14
Details	binding site for residue GPP A 201

Chain	Residue
A	ALA17
A	VAL19
A	ARG33
A	SER35
A	ALA43
A	LEU44
A	HIS48
A	THR80
A	PHE84
A	TYR93
A	SER95
A	PHE133
A	LEU136
A	HOH302

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GhlefgEsfeeCAaREVmEEtG

Chain	Residue	Details
E	GLY41-GLY62

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	532
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details