5GN9
Crystal structure of alternative oxidase from Trypanosoma brucei brucei complexed with cumarin derivative-17b
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0008199 | molecular_function | ferric iron binding |
| A | 0009916 | molecular_function | alternative oxidase activity |
| A | 0010230 | biological_process | alternative respiration |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0008199 | molecular_function | ferric iron binding |
| B | 0009916 | molecular_function | alternative oxidase activity |
| B | 0010230 | biological_process | alternative respiration |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0008199 | molecular_function | ferric iron binding |
| C | 0009916 | molecular_function | alternative oxidase activity |
| C | 0010230 | biological_process | alternative respiration |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0008199 | molecular_function | ferric iron binding |
| D | 0009916 | molecular_function | alternative oxidase activity |
| D | 0010230 | biological_process | alternative respiration |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0022904 | biological_process | respiratory electron transport chain |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 501 |
| Chain | Residue |
| A | GLU123 |
| A | GLU162 |
| A | HIS165 |
| A | GLU266 |
| A | FE502 |
| A | 6Y0503 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue FE A 502 |
| Chain | Residue |
| A | FE501 |
| A | 6Y0503 |
| A | GLU162 |
| A | GLU213 |
| A | GLU266 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue 6Y0 A 503 |
| Chain | Residue |
| A | ARG96 |
| A | ARG118 |
| A | CYS119 |
| A | LEU122 |
| A | GLU123 |
| A | ALA126 |
| A | GLU162 |
| A | GLU213 |
| A | ALA216 |
| A | THR219 |
| A | TYR220 |
| A | GLU266 |
| A | FE501 |
| A | FE502 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue FE B 501 |
| Chain | Residue |
| B | GLU123 |
| B | GLU162 |
| B | HIS165 |
| B | GLU266 |
| B | FE502 |
| B | 6Y0503 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue FE B 502 |
| Chain | Residue |
| B | GLU162 |
| B | GLU213 |
| B | GLU266 |
| B | FE501 |
| B | 6Y0503 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue 6Y0 B 503 |
| Chain | Residue |
| B | ARG96 |
| B | ARG118 |
| B | GLU123 |
| B | GLU162 |
| B | LEU212 |
| B | GLU213 |
| B | ALA216 |
| B | THR219 |
| B | TYR220 |
| B | GLU266 |
| B | FE501 |
| B | FE502 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue FE C 501 |
| Chain | Residue |
| C | GLU123 |
| C | GLU162 |
| C | GLU266 |
| C | FE502 |
| C | 6Y0503 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue FE C 502 |
| Chain | Residue |
| C | GLU162 |
| C | GLU213 |
| C | GLU266 |
| C | FE501 |
| C | 6Y0503 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue 6Y0 C 503 |
| Chain | Residue |
| C | ARG96 |
| C | CYS119 |
| C | LEU122 |
| C | GLU123 |
| C | LEU212 |
| C | GLU213 |
| C | ALA216 |
| C | THR219 |
| C | TYR220 |
| C | GLU266 |
| C | FE501 |
| C | FE502 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue FE D 501 |
| Chain | Residue |
| D | GLU123 |
| D | GLU162 |
| D | HIS165 |
| D | GLU266 |
| D | FE502 |
| D | 6Y0503 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue FE D 502 |
| Chain | Residue |
| D | GLU162 |
| D | GLU213 |
| D | GLU266 |
| D | FE501 |
| D | 6Y0503 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue 6Y0 D 503 |
| Chain | Residue |
| D | CYS119 |
| D | LEU122 |
| D | GLU123 |
| D | ALA126 |
| D | GLU162 |
| D | LEU212 |
| D | GLU213 |
| D | ALA216 |
| D | THR219 |
| D | TYR220 |
| D | GLU266 |
| D | FE501 |
| D | FE502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23487766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W54","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
