Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5GMA

Crystal structure of the P228A variant of Thermotoga maritima acetyl esterase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0005976	biological_process	polysaccharide metabolic process
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0030245	biological_process	cellulose catabolic process
A	0045491	biological_process	xylan metabolic process
A	0046555	molecular_function	acetylxylan esterase activity
A	0046872	molecular_function	metal ion binding
A	0047739	molecular_function	cephalosporin-C deacetylase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	1901266	biological_process	cephalosporin C metabolic process
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0005976	biological_process	polysaccharide metabolic process
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0030245	biological_process	cellulose catabolic process
B	0045491	biological_process	xylan metabolic process
B	0046555	molecular_function	acetylxylan esterase activity
B	0046872	molecular_function	metal ion binding
B	0047739	molecular_function	cephalosporin-C deacetylase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	1901266	biological_process	cephalosporin C metabolic process
C	0005509	molecular_function	calcium ion binding
C	0005737	cellular_component	cytoplasm
C	0005976	biological_process	polysaccharide metabolic process
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0030245	biological_process	cellulose catabolic process
C	0045491	biological_process	xylan metabolic process
C	0046555	molecular_function	acetylxylan esterase activity
C	0046872	molecular_function	metal ion binding
C	0047739	molecular_function	cephalosporin-C deacetylase activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
C	1901266	biological_process	cephalosporin C metabolic process
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0005976	biological_process	polysaccharide metabolic process
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0030245	biological_process	cellulose catabolic process
D	0045491	biological_process	xylan metabolic process
D	0046555	molecular_function	acetylxylan esterase activity
D	0046872	molecular_function	metal ion binding
D	0047739	molecular_function	cephalosporin-C deacetylase activity
D	0052689	molecular_function	carboxylic ester hydrolase activity
D	1901266	biological_process	cephalosporin C metabolic process
E	0005509	molecular_function	calcium ion binding
E	0005737	cellular_component	cytoplasm
E	0005976	biological_process	polysaccharide metabolic process
E	0016788	molecular_function	hydrolase activity, acting on ester bonds
E	0030245	biological_process	cellulose catabolic process
E	0045491	biological_process	xylan metabolic process
E	0046555	molecular_function	acetylxylan esterase activity
E	0046872	molecular_function	metal ion binding
E	0047739	molecular_function	cephalosporin-C deacetylase activity
E	0052689	molecular_function	carboxylic ester hydrolase activity
E	1901266	biological_process	cephalosporin C metabolic process
F	0005509	molecular_function	calcium ion binding
F	0005737	cellular_component	cytoplasm
F	0005976	biological_process	polysaccharide metabolic process
F	0016788	molecular_function	hydrolase activity, acting on ester bonds
F	0030245	biological_process	cellulose catabolic process
F	0045491	biological_process	xylan metabolic process
F	0046555	molecular_function	acetylxylan esterase activity
F	0046872	molecular_function	metal ion binding
F	0047739	molecular_function	cephalosporin-C deacetylase activity
F	0052689	molecular_function	carboxylic ester hydrolase activity
F	1901266	biological_process	cephalosporin C metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ACT C 401

Chain	Residue
C	GLN140
C	PRO142
C	GLY143
C	ARG147
F	GLN140
F	GLY143
F	ARG147

site_id	AC2
Number of Residues	7
Details	binding site for residue ACT D 401

Chain	Residue
A	ARG147
D	GLN140
D	PRO142
D	GLY143
D	ARG147
A	GLN140
A	GLY143

site_id	AC3
Number of Residues	9
Details	binding site for residue ACT E 401

Chain	Residue
B	GLN140
B	PRO142
B	GLY143
B	ARG147
E	GLN140
E	PRO142
E	GLY143
E	PHE144
E	ARG147

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:22411095

Chain	Residue	Details
A	SER188
B	SER188
C	SER188
D	SER188
E	SER188
F	SER188

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Charge relay system => ECO:0000250\|UniProtKB:P94388

Chain	Residue	Details
A	ASP274
E	HIS303
F	ASP274
F	HIS303
A	HIS303
B	ASP274
B	HIS303
C	ASP274
C	HIS303
D	ASP274
D	HIS303
E	ASP274

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P94388

Chain	Residue	Details
A	TYR92
B	TYR92
C	TYR92
D	TYR92
E	TYR92
F	TYR92

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: covalent => ECO:0000269\|PubMed:22411095

Chain	Residue	Details
A	SER188
B	SER188
C	SER188
D	SER188
E	SER188
F	SER188

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)