5GM1
Crystal structure of methyltransferase TleD complexed with SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| D | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| E | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| E | 0016740 | molecular_function | transferase activity |
| F | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| F | 0016740 | molecular_function | transferase activity |
| G | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| G | 0016740 | molecular_function | transferase activity |
| H | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| H | 0016740 | molecular_function | transferase activity |
| I | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| I | 0016740 | molecular_function | transferase activity |
| J | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| J | 0016740 | molecular_function | transferase activity |
| K | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| K | 0016740 | molecular_function | transferase activity |
| L | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| L | 0016740 | molecular_function | transferase activity |
| M | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| M | 0016740 | molecular_function | transferase activity |
| N | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| N | 0016740 | molecular_function | transferase activity |
| O | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| O | 0016740 | molecular_function | transferase activity |
| P | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| P | 0016740 | molecular_function | transferase activity |
| Q | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| Q | 0016740 | molecular_function | transferase activity |
| R | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| R | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | GLY85 |
| A | ALA136 |
| A | MET137 |
| A | ILE152 |
| A | GLU153 |
| A | SER154 |
| A | HIS157 |
| A | HOH415 |
| A | HOH430 |
| A | HOH438 |
| B | VAL17 |
| A | CYS86 |
| B | TYR21 |
| B | VAL36 |
| B | HIS37 |
| A | GLY87 |
| A | THR91 |
| A | ALA107 |
| A | VAL108 |
| A | GLN112 |
| A | ALA134 |
| A | ASP135 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue SAH B 301 |
| Chain | Residue |
| A | VAL17 |
| A | VAL36 |
| A | HIS37 |
| B | GLY85 |
| B | GLY87 |
| B | THR91 |
| B | ALA107 |
| B | VAL108 |
| B | GLN112 |
| B | ALA134 |
| B | ASP135 |
| B | ALA136 |
| B | MET137 |
| B | ILE152 |
| B | GLU153 |
| B | SER154 |
| B | HIS157 |
| B | MET158 |
| B | HOH406 |
| B | HOH418 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SAH B 302 |
| Chain | Residue |
| A | TYR244 |
| A | SER245 |
| B | TYR244 |
| B | SER245 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue SAH C 301 |
| Chain | Residue |
| C | GLY85 |
| C | CYS86 |
| C | GLY87 |
| C | ALA107 |
| C | VAL108 |
| C | GLN112 |
| C | ALA134 |
| C | ASP135 |
| C | ALA136 |
| C | MET137 |
| C | ILE152 |
| C | SER154 |
| C | HIS157 |
| C | HOH420 |
| D | VAL17 |
| D | TYR21 |
| D | VAL36 |
| D | HIS37 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue SAH D 301 |
| Chain | Residue |
| C | VAL17 |
| C | TYR21 |
| C | VAL36 |
| C | HIS37 |
| D | GLY85 |
| D | CYS86 |
| D | GLY87 |
| D | ALA107 |
| D | VAL108 |
| D | GLN112 |
| D | ASP135 |
| D | ALA136 |
| D | MET137 |
| D | ILE152 |
| D | GLU153 |
| D | SER154 |
| D | HIS157 |
| D | HOH410 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for residue SAH E 301 |
| Chain | Residue |
| F | HIS37 |
| E | GLY85 |
| E | GLY87 |
| E | THR91 |
| E | ALA107 |
| E | VAL108 |
| E | GLN112 |
| E | ALA134 |
| E | ASP135 |
| E | ALA136 |
| E | MET137 |
| E | ILE152 |
| E | GLU153 |
| E | SER154 |
| E | HIS157 |
| F | VAL17 |
| F | TYR21 |
| F | VAL36 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue SAH F 301 |
| Chain | Residue |
| E | VAL17 |
| E | TYR21 |
| E | VAL36 |
| E | HIS37 |
| F | GLY85 |
| F | CYS86 |
| F | GLY87 |
| F | THR91 |
| F | ALA107 |
| F | VAL108 |
| F | GLN112 |
| F | ALA134 |
| F | ASP135 |
| F | ALA136 |
| F | MET137 |
| F | ILE152 |
| F | GLU153 |
| F | SER154 |
| F | HIS157 |
| F | MET158 |
| F | HOH417 |
| F | HOH427 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for residue SAH G 301 |
| Chain | Residue |
| G | GLY85 |
| G | CYS86 |
| G | GLY87 |
| G | ALA107 |
| G | VAL108 |
| G | GLN112 |
| G | ALA134 |
| G | ASP135 |
| G | ALA136 |
| G | MET137 |
| G | ILE152 |
| G | GLU153 |
| G | SER154 |
| G | HIS157 |
| G | MET158 |
| H | VAL17 |
| H | TYR21 |
| H | VAL36 |
| H | HIS37 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue SAH H 301 |
| Chain | Residue |
| G | VAL17 |
| G | VAL36 |
| G | HIS37 |
| G | HOH417 |
| H | GLY85 |
| H | CYS86 |
| H | GLY87 |
| H | THR91 |
| H | VAL108 |
| H | GLN112 |
| H | ALA134 |
| H | ASP135 |
| H | ALA136 |
| H | MET137 |
| H | ILE152 |
| H | GLU153 |
| H | SER154 |
| H | HIS157 |
| H | MET158 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH I 301 |
| Chain | Residue |
| I | GLY85 |
| I | CYS86 |
| I | GLY87 |
| I | THR91 |
| I | ALA107 |
| I | VAL108 |
| I | GLN112 |
| I | ALA134 |
| I | ASP135 |
| I | ALA136 |
| I | MET137 |
| I | ILE152 |
| I | GLU153 |
| I | SER154 |
| I | HIS157 |
| I | MET158 |
| J | VAL17 |
| J | TYR21 |
| J | VAL36 |
| J | HIS37 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue SAH J 301 |
| Chain | Residue |
| I | VAL17 |
| I | TYR21 |
| I | VAL36 |
| I | HIS37 |
| J | GLY85 |
| J | CYS86 |
| J | GLY87 |
| J | ALA107 |
| J | VAL108 |
| J | GLN112 |
| J | ALA134 |
| J | ASP135 |
| J | ALA136 |
| J | MET137 |
| J | ILE152 |
| J | GLU153 |
| J | SER154 |
| J | HIS157 |
| J | MET158 |
| site_id | AD3 |
| Number of Residues | 18 |
| Details | binding site for residue SAH K 301 |
| Chain | Residue |
| K | GLY85 |
| K | GLY87 |
| K | THR91 |
| K | ALA107 |
| K | VAL108 |
| K | GLN112 |
| K | ALA134 |
| K | ASP135 |
| K | ALA136 |
| K | MET137 |
| K | ILE152 |
| K | SER154 |
| K | HIS157 |
| K | MET158 |
| L | VAL17 |
| L | TYR21 |
| L | VAL36 |
| L | HIS37 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for residue SAH L 301 |
| Chain | Residue |
| K | VAL17 |
| K | TYR21 |
| K | VAL36 |
| K | HIS37 |
| L | GLY85 |
| L | CYS86 |
| L | GLY87 |
| L | ALA107 |
| L | VAL108 |
| L | GLN112 |
| L | ALA134 |
| L | ASP135 |
| L | ALA136 |
| L | MET137 |
| L | ILE152 |
| L | SER154 |
| L | HIS157 |
| L | MET158 |
| L | HOH404 |
| site_id | AD5 |
| Number of Residues | 18 |
| Details | binding site for residue SAH M 301 |
| Chain | Residue |
| M | GLY85 |
| M | CYS86 |
| M | GLY87 |
| M | THR91 |
| M | ALA107 |
| M | VAL108 |
| M | GLN112 |
| M | ALA134 |
| M | ASP135 |
| M | ALA136 |
| M | MET137 |
| M | ILE152 |
| M | SER154 |
| M | HIS157 |
| M | MET158 |
| N | VAL17 |
| N | VAL36 |
| N | HIS37 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for residue SAH N 301 |
| Chain | Residue |
| M | VAL17 |
| M | VAL36 |
| M | HIS37 |
| M | HOH423 |
| N | GLY85 |
| N | CYS86 |
| N | GLY87 |
| N | ALA107 |
| N | VAL108 |
| N | GLN112 |
| N | ALA134 |
| N | ASP135 |
| N | ALA136 |
| N | MET137 |
| N | ILE152 |
| N | GLU153 |
| N | SER154 |
| N | HIS157 |
| site_id | AD7 |
| Number of Residues | 18 |
| Details | binding site for residue SAH O 301 |
| Chain | Residue |
| O | GLY85 |
| O | GLY87 |
| O | THR91 |
| O | ALA107 |
| O | VAL108 |
| O | GLN112 |
| O | ASP135 |
| O | ALA136 |
| O | MET137 |
| O | ILE152 |
| O | GLU153 |
| O | SER154 |
| O | HIS157 |
| O | MET158 |
| P | VAL17 |
| P | TYR21 |
| P | VAL36 |
| P | HIS37 |
| site_id | AD8 |
| Number of Residues | 18 |
| Details | binding site for residue SAH P 301 |
| Chain | Residue |
| O | VAL17 |
| O | TYR21 |
| O | VAL36 |
| O | HIS37 |
| P | GLY85 |
| P | ALA107 |
| P | VAL108 |
| P | GLN112 |
| P | ALA134 |
| P | ASP135 |
| P | ALA136 |
| P | MET137 |
| P | ILE152 |
| P | GLU153 |
| P | SER154 |
| P | HIS157 |
| P | MET158 |
| P | HOH425 |
| site_id | AD9 |
| Number of Residues | 19 |
| Details | binding site for residue SAH Q 301 |
| Chain | Residue |
| Q | GLY85 |
| Q | CYS86 |
| Q | GLY87 |
| Q | THR91 |
| Q | ALA107 |
| Q | VAL108 |
| Q | GLN112 |
| Q | ALA134 |
| Q | ASP135 |
| Q | ALA136 |
| Q | MET137 |
| Q | ILE152 |
| Q | GLU153 |
| Q | SER154 |
| Q | HIS157 |
| Q | MET158 |
| R | VAL17 |
| R | VAL36 |
| R | HIS37 |
| site_id | AE1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH R 301 |
| Chain | Residue |
| Q | VAL17 |
| Q | TYR21 |
| Q | VAL36 |
| Q | HIS37 |
| R | GLY85 |
| R | CYS86 |
| R | GLY87 |
| R | ALA107 |
| R | VAL108 |
| R | GLN112 |
| R | ALA134 |
| R | ASP135 |
| R | ALA136 |
| R | MET137 |
| R | ILE152 |
| R | GLU153 |
| R | SER154 |
| R | HIS157 |
| R | MET158 |
| R | HOH415 |
