5GJ4

Structure of NS2B-NS3 Protease from Zika Virus caught after self-cleavage

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0044423	cellular_component	virion component
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0005524	molecular_function	ATP binding
C	0004252	molecular_function	serine-type endopeptidase activity
C	0044423	cellular_component	virion component
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0005524	molecular_function	ATP binding
E	0004252	molecular_function	serine-type endopeptidase activity
E	0044423	cellular_component	virion component
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0005524	molecular_function	ATP binding
G	0004252	molecular_function	serine-type endopeptidase activity
G	0044423	cellular_component	virion component
H	0003723	molecular_function	RNA binding
H	0003724	molecular_function	RNA helicase activity
H	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL B 2001

Chain	Residue
B	ARG105
B	ALA106
E	HOH219
F	ALA106

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL D 201

Chain	Residue
C	HOH213
D	ARG105
D	ALA106
H	ALA106

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
B	HIS51
B	ASP75
D	HIS51
D	ASP75
F	HIS51
F	ASP75
H	HIS51
H	ASP75

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860, ECO:0000269|PubMed:29526431

Chain	Residue	Details
B	SER135
D	SER135
F	SER135
H	SER135

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