5GIW

Solution NMR structure of Humanin containing a D-isomerized serine residue

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0001664	molecular_function	G protein-coupled receptor binding
X	0005102	molecular_function	signaling receptor binding
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006915	biological_process	apoptotic process
X	0007005	biological_process	mitochondrion organization
X	0007267	biological_process	cell-cell signaling
X	0030595	biological_process	leukocyte chemotaxis
X	0031514	cellular_component	motile cilium
X	0032692	biological_process	negative regulation of interleukin-1 production
X	0032701	biological_process	negative regulation of interleukin-18 production
X	0036126	cellular_component	sperm flagellum
X	0042802	molecular_function	identical protein binding
X	0043066	biological_process	negative regulation of apoptotic process
X	0043524	biological_process	negative regulation of neuron apoptotic process
X	0048018	molecular_function	receptor ligand activity
X	0048019	molecular_function	receptor antagonist activity
X	0048471	cellular_component	perinuclear region of cytoplasm
X	0050728	biological_process	negative regulation of inflammatory response
X	0097225	cellular_component	sperm midpiece
X	0097435	biological_process	supramolecular fiber organization
X	0097696	biological_process	cell surface receptor signaling pathway via STAT
X	0150079	biological_process	negative regulation of neuroinflammatory response
X	1900118	biological_process	negative regulation of execution phase of apoptosis
X	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
X	1902883	biological_process	negative regulation of response to oxidative stress
X	1904646	biological_process	cellular response to amyloid-beta
X	1905907	biological_process	negative regulation of amyloid fibril formation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Region: {"description":"Sufficient to interact with BID and BIM and to suppress BID and BIM activity","evidences":[{"source":"PubMed","id":"15661735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15661737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Sufficient to interact with MPP8","evidences":[{"source":"PubMed","id":"23532874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"Required for secretion","evidences":[{"source":"PubMed","id":"12860203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---