5GIF

Crystal Structure of Drosophila melanogaster E47D Dopamine N-Acetyltransferase in Binary Complex with Acetyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue D1D A 301

Chain	Residue
A	PHE43
A	ASP47
A	LEU49
A	ASN50
A	MET121
A	SER182
A	HOH526

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site_id	AC2
Number of Residues	4
Details	binding site for residue D1D A 302

Chain	Residue
A	ACO303
A	HOH445
A	PRO48
A	TYR185

---

site_id	AC3
Number of Residues	34
Details	binding site for residue ACO A 303

Chain	Residue
A	PHE43
A	ASP46
A	ASP47
A	PRO48
A	GLY143
A	LYS144
A	ILE145
A	LEU146
A	SER147
A	VAL148
A	ARG153
A	GLY154
A	LEU155
A	GLY156
A	ILE157
A	ALA158
A	LEU180
A	SER182
A	LYS192
A	D1D302
A	HOH427
A	HOH430
A	HOH433
A	HOH446
A	HOH447
A	HOH451
A	HOH457
A	HOH474
A	HOH481
A	HOH489
A	HOH504
A	HOH531
A	HOH543
A	HOH573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	LEU146
A	GLY154

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Has a role in the catalytic activity => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	ASP47
A	SER182
A	SER186

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Might be involved in substrate binding => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	TYR64

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Regulates binding affinity for coenzyme A (CoASH) => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	ARG153

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Acetyl-CoA => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	LYS192

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