5GI7

Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-phenylethylamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	binding site for residue COA A 301

Chain	Residue
A	ASP46
A	GLY154
A	LEU155
A	GLY156
A	ILE157
A	ALA158
A	CYS181
A	SER182
A	SER186
A	LYS192
A	54W302
A	PRO48
A	D1D304
A	HOH417
A	HOH427
A	HOH436
A	HOH448
A	HOH460
A	HOH465
A	HOH468
A	HOH471
A	HOH494
A	ASP132
A	HOH497
A	HOH504
A	HOH524
A	HOH534
A	HOH555
A	HOH586
A	HOH588
A	VAL133
A	PRO135
A	LEU146
A	SER147
A	VAL148
A	ARG153

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 54W A 302

Chain	Residue
A	PHE43
A	GLU47
A	ASN50
A	MET121
A	GLY143
A	LYS144
A	ILE145
A	LEU146
A	VAL179
A	LEU180
A	COA301

---

site_id	AC3
Number of Residues	9
Details	binding site for residue 54W A 303

Chain	Residue
A	THR41
A	PHE42
A	GLU197
A	ARG200
A	MET201
A	VAL221
A	GLY222
A	ILE223
A	GLN224

---

site_id	AC4
Number of Residues	8
Details	binding site for residue D1D A 304

Chain	Residue
A	PRO48
A	HIS196
A	GLU229
A	COA301
A	HOH450
A	HOH510
A	HOH555
A	HOH567

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	LEU146
A	GLY154

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Has a role in the catalytic activity => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	GLU47
A	SER182
A	SER186

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Might be involved in substrate binding => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	TYR64

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Regulates binding affinity for coenzyme A (CoASH) => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	ARG153

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Acetyl-CoA => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	LYS192

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