5GI7
Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-phenylethylamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue COA A 301 |
| Chain | Residue |
| A | ASP46 |
| A | GLY154 |
| A | LEU155 |
| A | GLY156 |
| A | ILE157 |
| A | ALA158 |
| A | CYS181 |
| A | SER182 |
| A | SER186 |
| A | LYS192 |
| A | 54W302 |
| A | PRO48 |
| A | D1D304 |
| A | HOH417 |
| A | HOH427 |
| A | HOH436 |
| A | HOH448 |
| A | HOH460 |
| A | HOH465 |
| A | HOH468 |
| A | HOH471 |
| A | HOH494 |
| A | ASP132 |
| A | HOH497 |
| A | HOH504 |
| A | HOH524 |
| A | HOH534 |
| A | HOH555 |
| A | HOH586 |
| A | HOH588 |
| A | VAL133 |
| A | PRO135 |
| A | LEU146 |
| A | SER147 |
| A | VAL148 |
| A | ARG153 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 54W A 302 |
| Chain | Residue |
| A | PHE43 |
| A | GLU47 |
| A | ASN50 |
| A | MET121 |
| A | GLY143 |
| A | LYS144 |
| A | ILE145 |
| A | LEU146 |
| A | VAL179 |
| A | LEU180 |
| A | COA301 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 54W A 303 |
| Chain | Residue |
| A | THR41 |
| A | PHE42 |
| A | GLU197 |
| A | ARG200 |
| A | MET201 |
| A | VAL221 |
| A | GLY222 |
| A | ILE223 |
| A | GLN224 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue D1D A 304 |
| Chain | Residue |
| A | PRO48 |
| A | HIS196 |
| A | GLU229 |
| A | COA301 |
| A | HOH450 |
| A | HOH510 |
| A | HOH555 |
| A | HOH567 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 73 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22716280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TE4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Has a role in the catalytic activity","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Might be involved in substrate binding","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Regulates binding affinity for coenzyme A (CoASH)","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acetyl-CoA","evidences":[{"source":"PubMed","id":"22716280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TE4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
