5GI6
Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase Bound to CoA and Phenylethylamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PEA A 301 |
| Chain | Residue |
| A | GLU47 |
| A | ASN50 |
| A | LYS144 |
| A | LEU180 |
| A | SER182 |
| A | HOH454 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | binding site for residue COA A 302 |
| Chain | Residue |
| A | LEU146 |
| A | VAL148 |
| A | ARG153 |
| A | GLY154 |
| A | LEU155 |
| A | GLY156 |
| A | ILE157 |
| A | ALA158 |
| A | CYS181 |
| A | SER182 |
| A | SER183 |
| A | TYR185 |
| A | SER186 |
| A | ARG188 |
| A | VAL189 |
| A | LYS192 |
| A | GLU197 |
| A | VAL198 |
| A | HOH407 |
| A | HOH408 |
| A | HOH413 |
| A | HOH417 |
| A | HOH423 |
| A | HOH443 |
| A | HOH446 |
| A | HOH450 |
| A | HOH451 |
| A | HOH458 |
| A | HOH466 |
| A | HOH474 |
| A | HOH498 |
| A | HOH504 |
| A | HOH522 |
| A | ASP46 |
| A | GLU47 |
| A | PRO48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 73 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22716280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TE4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Has a role in the catalytic activity","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Might be involved in substrate binding","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Regulates binding affinity for coenzyme A (CoASH)","evidences":[{"source":"PubMed","id":"25406072","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acetyl-CoA","evidences":[{"source":"PubMed","id":"22716280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TE4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
