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5GHI

Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues31
Detailsbinding site for residue 8DG A 201
ChainResidue
ATYR7
AGLU56
APHE72
AMET81
ATRP117
AASP119
AASP120
ATRP123
ANA202
ANA203
AHOH303
ATHR8
AHOH310
AHOH334
AHOH347
AHOH375
AHOH380
AHOH382
AHOH401
AHOH424
AHOH425
AHOH441
ALEU9
AHOH445
BLYS130
ALYS23
APHE27
AASN33
AGLY36
AGLY37
ALYS38

site_idAC2
Number of Residues7
Detailsbinding site for residue NA A 202
ChainResidue
ALYS23
AGLY36
AGLU56
A8DG201
ANA203
AHOH399
AHOH425

site_idAC3
Number of Residues7
Detailsbinding site for residue NA A 203
ChainResidue
AGLU52
AGLU56
A8DG201
ANA202
AHOH301
AHOH303
AHOH310

site_idAC4
Number of Residues21
Detailsbinding site for residue 8DG B 201
ChainResidue
BTYR7
BTHR8
BLEU9
BLYS23
BASN33
BGLY36
BGLY37
BLYS38
BPHE72
BMET81
BTRP117
BASP119
BASP120
BTRP123
BNA202
BHOH304
BHOH305
BHOH343
BHOH368
BHOH375
BHOH396

site_idAC5
Number of Residues5
Detailsbinding site for residue NA B 202
ChainResidue
BGLY36
BGLU56
B8DG201
BHOH304
BHOH430

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
ALEU11
AGLN14
APRO15
ALEU59
BLEU11
BGLN14
BPRO15
BLEU59

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM
ChainResidueDetails
AGLY76
BGLY76

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PDB entries from 2024-07-17

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