5GAQ

Cryo-EM structure of the Lysenin Pore

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006811	biological_process	monoatomic ion transport
A	0031640	biological_process	killing of cells of another organism
A	0035821	biological_process	modulation of process of another organism
A	0042742	biological_process	defense response to bacterium
A	0044218	cellular_component	other organism cell membrane
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0006811	biological_process	monoatomic ion transport
B	0031640	biological_process	killing of cells of another organism
B	0035821	biological_process	modulation of process of another organism
B	0042742	biological_process	defense response to bacterium
B	0044218	cellular_component	other organism cell membrane
B	0090729	molecular_function	toxin activity
C	0005576	cellular_component	extracellular region
C	0006811	biological_process	monoatomic ion transport
C	0031640	biological_process	killing of cells of another organism
C	0035821	biological_process	modulation of process of another organism
C	0042742	biological_process	defense response to bacterium
C	0044218	cellular_component	other organism cell membrane
C	0090729	molecular_function	toxin activity
D	0005576	cellular_component	extracellular region
D	0006811	biological_process	monoatomic ion transport
D	0031640	biological_process	killing of cells of another organism
D	0035821	biological_process	modulation of process of another organism
D	0042742	biological_process	defense response to bacterium
D	0044218	cellular_component	other organism cell membrane
D	0090729	molecular_function	toxin activity
E	0005576	cellular_component	extracellular region
E	0006811	biological_process	monoatomic ion transport
E	0031640	biological_process	killing of cells of another organism
E	0035821	biological_process	modulation of process of another organism
E	0042742	biological_process	defense response to bacterium
E	0044218	cellular_component	other organism cell membrane
E	0090729	molecular_function	toxin activity
F	0005576	cellular_component	extracellular region
F	0006811	biological_process	monoatomic ion transport
F	0031640	biological_process	killing of cells of another organism
F	0035821	biological_process	modulation of process of another organism
F	0042742	biological_process	defense response to bacterium
F	0044218	cellular_component	other organism cell membrane
F	0090729	molecular_function	toxin activity
G	0005576	cellular_component	extracellular region
G	0006811	biological_process	monoatomic ion transport
G	0031640	biological_process	killing of cells of another organism
G	0035821	biological_process	modulation of process of another organism
G	0042742	biological_process	defense response to bacterium
G	0044218	cellular_component	other organism cell membrane
G	0090729	molecular_function	toxin activity
H	0005576	cellular_component	extracellular region
H	0006811	biological_process	monoatomic ion transport
H	0031640	biological_process	killing of cells of another organism
H	0035821	biological_process	modulation of process of another organism
H	0042742	biological_process	defense response to bacterium
H	0044218	cellular_component	other organism cell membrane
H	0090729	molecular_function	toxin activity
I	0005576	cellular_component	extracellular region
I	0006811	biological_process	monoatomic ion transport
I	0031640	biological_process	killing of cells of another organism
I	0035821	biological_process	modulation of process of another organism
I	0042742	biological_process	defense response to bacterium
I	0044218	cellular_component	other organism cell membrane
I	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. ETRTVTATHSI

Chain	Residue	Details
A	GLU50-ILE60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	639
Details	Region: {"description":"N-terminal cap domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	657
Details	Region: {"description":"Beta-hairpin domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1260
Details	Region: {"description":"C-terminal receptor-binding domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22819216","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	27
Details	Site: {"description":"Crucial for binding sphingomyelin and inducing hemolysis","evidences":[{"source":"PubMed","id":"15274631","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Site: {"description":"Crucial for binding sphingomyelin and important for inducing hemolysis","evidences":[{"source":"PubMed","id":"15274631","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Site: {"description":"Important for activity"}

Chain

Residue

Details

---