5GAQ

Cryo-EM structure of the Lysenin Pore

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
B	0005576	cellular_component	extracellular region
C	0005576	cellular_component	extracellular region
D	0005576	cellular_component	extracellular region
E	0005576	cellular_component	extracellular region
F	0005576	cellular_component	extracellular region
G	0005576	cellular_component	extracellular region
H	0005576	cellular_component	extracellular region
I	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. ETRTVTATHSI

Chain	Residue	Details
A	GLU50-ILE60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	639
Details	Region: {"description":"N-terminal cap domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	657
Details	Region: {"description":"Beta-hairpin domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1260
Details	Region: {"description":"C-terminal receptor-binding domain","evidences":[{"source":"PubMed","id":"27048994","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22819216","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	27
Details	Site: {"description":"Crucial for binding sphingomyelin and inducing hemolysis","evidences":[{"source":"PubMed","id":"15274631","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Site: {"description":"Crucial for binding sphingomyelin and important for inducing hemolysis","evidences":[{"source":"PubMed","id":"15274631","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Site: {"description":"Important for activity"}

Chain

Residue

Details

---